8GKG
| |
3V2X
| Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2 | Descriptor: | Ankyrin repeat family A protein 2, Low-density lipoprotein receptor-related protein 2 | Authors: | Lam, R, Xu, C, Bian, C.B, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2011-12-12 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
|
|
8GF8
| Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, ... | Authors: | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-03-07 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat Commun, 14, 2023
|
|
3V2O
| Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2 | Descriptor: | Ankyrin repeat family A protein 2, Low-density lipoprotein receptor-related protein 2 | Authors: | Lam, R, Xu, C, Bian, C.B, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2011-12-12 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
|
|
3V31
| Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2 | Descriptor: | Ankyrin repeat family A protein 2, CHLORIDE ION, Histone deacetylase 4, ... | Authors: | Lam, R, Xu, C, Bian, C.B, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2011-12-12 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock. Sci.Signal., 5, 2012
|
|
3V79
| Structure of human Notch1 transcription complex including CSL, RAM, ANK, and MAML-1 on HES-1 promoter DNA sequence | Descriptor: | DNA 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', DNA 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ... | Authors: | Nam, Y, Sliz, P, Blacklow, S. | Deposit date: | 2011-12-20 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. Structure, 20, 2012
|
|
3T9K
| Crystal Structure of ACAP1 C-portion mutant S554D fused with integrin beta1 peptide | Descriptor: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1,Peptide from Integrin beta-1, SULFATE ION, ... | Authors: | Sun, F, Pang, X, Zhang, K, Ma, J, Zhou, Q. | Deposit date: | 2011-08-03 | Release date: | 2012-07-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
|
|
8TF3
| Wildtype rabbit TRPV5 into nanodiscs in complex with econazole | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | Authors: | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | Deposit date: | 2023-07-07 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
|
|
8TF2
| |
8TF4
| Wildtype rabbit TRPV5 into nanodiscs in the presence of PI(4,5)P2 and econazole | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, ERGOSTEROL, ... | Authors: | De Jesus-Perez, J.J, Fluck, E.C, Moiseenkova-Bell, V.Y. | Deposit date: | 2023-07-07 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural mechanism of TRPV5 inhibition by econazole. Structure, 32, 2024
|
|
6LGP
| cryo-EM structure of TRPV3 in lipid nanodisc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, DIUNDECYL PHOSPHATIDYL CHOLINE, Transient receptor potential cation channel subfamily V member 3 | Authors: | Shimada, H, Kusakizako, T, Nishizawa, T, Nureki, O. | Deposit date: | 2019-12-05 | Release date: | 2020-06-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism. Nat.Struct.Mol.Biol., 27, 2020
|
|
8U3A
| TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 1 (monomer) | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U4D
| TRPV1 in nanodisc bound with PI-Br4, consensus structure | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-10 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U3J
| TRPV1 in nanodisc bound with empty vanilloid binding pocket at 4C | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U30
| TRPV1 in nanodisc bound with diC8-PIP2 in the closed state | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily V member 1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U3C
| TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 2 (monomer) | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U43
| TRPV1 in nanodisc bound with PIP2-Br4 | Descriptor: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-08 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U2Z
| TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, SODIUM ION, ... | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
8U3L
| TRPV1 in nanodisc bound with empty vanilloid binding pocket at 25C | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | Authors: | Arnold, W.R, Julius, D, Cheng, Y. | Deposit date: | 2023-09-07 | Release date: | 2024-05-08 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 31, 2024
|
|
6MHS
| Structure of the human TRPV3 channel in a putative sensitized conformation | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
|
|
6MHX
| Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (2) | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
|
|
6MHW
| Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (1) | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
|
|
6MHV
| Structure of human TRPV3 in the presence of 2-APB in C4 symmetry | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
|
|
6MHO
| Structure of the human TRPV3 channel in the apo conformation | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | Deposit date: | 2018-09-18 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
|
|
6O20
| Cryo-EM structure of TRPV5 with calmodulin bound | Descriptor: | CALCIUM ION, Calmodulin, Transient receptor potential cation channel subfamily V member 5 | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | Deposit date: | 2019-02-22 | Release date: | 2019-04-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|