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6ROY
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BU of 6roy by Molmil
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based inhibitory motif
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, immune receptor tyrosine-based inhibitory motif (ITIM)
Authors:Krausze, J, Sikorska, J, Carlomagno, T.
Deposit date:2019-05-13
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of SHP2 activation by PD-1 stimulation.
Sci Adv, 6, 2020
6TWR
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BU of 6twr by Molmil
Structure of a constitutively active CAT-PRD1 mutant of the antiterminator LicT protein.
Descriptor: Beta-glucoside bgl operon antiterminator BglG family
Authors:Demene, H, Declerck, N, Yinshan, Y.
Deposit date:2020-01-13
Release date:2021-04-14
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Resolving the activation mechanism of the D99N antiterminator LicT protein.
J.Struct.Biol., 213, 2021
5L2R
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BU of 5l2r by Molmil
Crystal structure of fumarate hydratase from Leishmania major
Descriptor: (2S)-2-hydroxybutanedioic acid, DI(HYDROXYETHYL)ETHER, Fumarate hydratase, ...
Authors:Feliciano, P.R, Drennan, C.L, Nonato, M.C.
Deposit date:2016-08-02
Release date:2016-08-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.
Proc.Natl.Acad.Sci.USA, 113, 2016
6MC3
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BU of 6mc3 by Molmil
Crystal structure of a tetrameric DNA fold-back quadruplex
Descriptor: DNA (5'-D(*CP*GP*TP*GP*AP*GP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Chu, B, Paukstelis, P.J.
Deposit date:2018-08-30
Release date:2018-11-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Crystal Structure of a Tetrameric DNA Fold-Back Quadruplex.
J. Am. Chem. Soc., 140, 2018
8A9J
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BU of 8a9j by Molmil
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323 (consensus reconstruction)
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-06-28
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
2JLP
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BU of 2jlp by Molmil
Crystal structure of human extracellular copper-zinc superoxide dismutase.
Descriptor: COPPER (II) ION, EXTRACELLULAR SUPEROXIDE DISMUTASE (CU-ZN), THIOCYANATE ION, ...
Authors:Antonyuk, S.V, Strange, R.W, Marklund, S.L, Hasnain, S.S.
Deposit date:2008-09-14
Release date:2009-03-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of Human Extracellular Copper-Zinc Superoxide Dismutase at 1.7 A Resolution: Insights Into Heparin and Collagen Binding.
J.Mol.Biol., 388, 2009
7ZH3
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BU of 7zh3 by Molmil
USP1 bound to ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ZINC ION
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-04-05
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
8PZQ
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BU of 8pzq by Molmil
Model for focused reconstruction of influenza A RNP-like particle
Descriptor: Nucleoprotein, RNA (5'P-(UC)6-FAM3')
Authors:Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T.
Deposit date:2023-07-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation.
Sci Adv, 9, 2023
6RSQ
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BU of 6rsq by Molmil
Helical folded domain of mouse CAP1
Descriptor: Adenylyl cyclase-associated protein 1, GLYCEROL
Authors:Kotila, T, Kogan, K, Lappalainen, P.
Deposit date:2019-05-22
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin.
Nat Commun, 10, 2019
6AC5
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BU of 6ac5 by Molmil
Crystal structure of RIPK1 death domain GlcNAcylated by EPEC effector NleB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION
Authors:Ding, J, Shao, F.
Deposit date:2018-07-25
Release date:2019-05-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector.
Mol.Cell, 74, 2019
6MG4
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BU of 6mg4 by Molmil
Structure of full-length human lambda-6A light chain JTO
Descriptor: JTO light chain
Authors:Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
Deposit date:2018-09-12
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
5IKF
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BU of 5ikf by Molmil
Crystal structure of the C-terminal domain of the Mit1 nucleosome remodeler in complex with Clr1
Descriptor: CHLORIDE ION, Chromatin remodeling factor mit1, Cryptic loci regulator protein 1, ...
Authors:Brugger, C, Schalch, T.
Deposit date:2016-03-03
Release date:2016-04-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.
Mol.Cell, 62, 2016
5IIV
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BU of 5iiv by Molmil
GCN4p pH 1.5
Descriptor: General control protein GCN4
Authors:Brady, M.R, Kaplan, A.R, Alexandrescu, A.T.
Deposit date:2016-03-01
Release date:2017-03-15
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Structures of GCN4p Are Largely Conserved When Ion Pairs Are Disrupted at Acidic pH but Show a Relaxation of the Coiled Coil Superhelix.
Biochemistry, 56, 2017
6LKE
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BU of 6lke by Molmil
in meso full-length rat KMO in complex with an inhibitor identified via DNA-encoded chemical library screening
Descriptor: 4-chloranyl-2-[[5-chloranyl-2-(5-methoxy-1,3-dihydroisoindol-2-yl)-1,3-thiazol-4-yl]carbonyl-methyl-amino]-5-fluoranyl-benzoic acid, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mimasu, S, Yamagishi, H, Kiyohara, M, Hupp, D.C, Liu, J, Kakefuda, K, Okuda, T.
Deposit date:2019-12-19
Release date:2020-12-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition.
Commun Biol, 4, 2021
6AHY
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BU of 6ahy by Molmil
Wnt signaling complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Hirai, H, Arimori, T, Matoba, K, Mihara, E, Takagi, J.
Deposit date:2018-08-21
Release date:2019-05-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a mammalian Wnt-frizzled complex.
Nat.Struct.Mol.Biol., 26, 2019
5L0J
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BU of 5l0j by Molmil
Human vinculin R903Q, D907R, R910T mutant(residues 891-1066)
Descriptor: Vinculin
Authors:Chinthalapudi, K, Izard, T.
Deposit date:2016-07-27
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Proc.Natl.Acad.Sci.USA, 113, 2016
8G2Y
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BU of 8g2y by Molmil
Cryo-EM structure of ADGRF1 coupled to miniGs/q
Descriptor: Adhesion G-protein-coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Jones, D, Rawson, S, Blacklow, S.
Deposit date:2023-02-06
Release date:2023-05-10
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.
Nat Commun, 14, 2023
7JMN
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BU of 7jmn by Molmil
Tail module of Mediator complex
Descriptor: MED15, Mediator of RNA polymerase II transcription subunit 14, Mediator of RNA polymerase II transcription subunit 16, ...
Authors:Zhang, H.Q, Chen, D.C.
Deposit date:2020-08-02
Release date:2021-03-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Mediator structure and conformation change.
Mol.Cell, 81, 2021
6AHG
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BU of 6ahg by Molmil
Trimeric structure of concanavalin A from Canavalia ensiformis
Descriptor: CADMIUM ION, CALCIUM ION, Concanavalin-A,Concanavalin-A
Authors:Park, J.H, Kim, D.S, Park, Y.R, Lee, S.J.
Deposit date:2018-08-18
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Cadmium-substituted concanavalin A and its trimeric complexation
J. Microbiol. Biotechnol., 28(12), 2018
8PZP
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BU of 8pzp by Molmil
Model for influenza A virus helical ribonucleoprotein-like structure
Descriptor: Nucleoprotein, RNA (5'P-(UC)6-FAM3')
Authors:Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T.
Deposit date:2023-07-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (8.7 Å)
Cite:Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation.
Sci Adv, 9, 2023
6UTN
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BU of 6utn by Molmil
Native E. coli Glyceraldehyde 3-phosphate dehydrogenase
Descriptor: ACETATE ION, Glyceraldehyde-3-phosphate dehydrogenase, PHOSPHATE ION, ...
Authors:Rodriguez-Hernandez, A, Romo-Arevalo, E, Rodriguez-Romero, A.
Deposit date:2019-10-29
Release date:2019-12-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A Novel Substrate-Binding Site in the X-Ray Structure of an Oxidized E. coli Glyceraldehyde 3-Phosphate Dehydrogenase Elucidated by Single-Wavelength Anomalous Dispersion
Crystals, 9, 2019
6S5D
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BU of 6s5d by Molmil
Square conformation of KtrA R16A mutant ring with bound ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, MAGNESIUM ION
Authors:Teixeira-Duarte, C.M, Fonseca, F, Morais-Cabral, J.H.
Deposit date:2019-07-01
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.393 Å)
Cite:Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site.
Elife, 8, 2019
6S5G
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BU of 6s5g by Molmil
Non-square conformation of KtrA A80P mutant ring with bound ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ktr system potassium uptake protein A
Authors:Teixeira-Duarte, C.M, Fonseca, F, Morais-Cabral, J.H.
Deposit date:2019-07-01
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.33 Å)
Cite:Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site.
Elife, 8, 2019
8FOI
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BU of 8foi by Molmil
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, DODECANE, ...
Authors:Sun, C, Gouaux, E.
Deposit date:2022-12-30
Release date:2023-09-20
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Nature, 622, 2023
6LT7
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BU of 6lt7 by Molmil
Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP
Descriptor: 1,2-ETHANEDIOL, 50-mer RNA, Ribonuclease P protein subunit p20, ...
Authors:Huang, J, Yin, C.
Deposit date:2020-01-21
Release date:2021-01-27
Last modified:2021-04-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP.
J.Struct.Biol., 213, 2021

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數據於2024-07-17公開中

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