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2GMT	THREE-DIMENSIONAL STRUCTURE OF CHYMOTRYPSIN INACTIVATED WITH (2S) N-ACETYL-L-ALANYL-L-PHENYLALANYL-CHLOROETHYL KETONE: IMPLICATIONS FOR THE MECHANISM OF INACTIVATION OF SERINE PROTEASES BY CHLOROKETONES Descriptor: (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE, GAMMA-CHYMOTRYPSIN Authors: Kreutter, K, Steinmetz, A.C.U, Liang, T.-C, Prorok, M, Abeles, R, Ringe, D. Deposit date: 1994-09-07 Release date: 1994-11-01 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones. Biochemistry, 33, 1994
1ACB	CRYSTAL AND MOLECULAR STRUCTURE OF THE BOVINE ALPHA-CHYMOTRYPSIN-EGLIN C COMPLEX AT 2.0 ANGSTROMS RESOLUTION Descriptor: ALPHA-CHYMOTRYPSIN, Eglin C Authors: Bolognesi, M, Frigerio, F, Coda, A, Pugliese, L, Lionetti, C, Menegatti, E, Amiconi, G, Schnebli, H.P, Ascenzi, P. Deposit date: 1991-11-08 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal and molecular structure of the bovine alpha-chymotrypsin-eglin c complex at 2.0 A resolution. J.Mol.Biol., 225, 1992
6XJA	Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate Descriptor: Immunoglobulin A1 protease, Immunoglobulin alpha-1 heavy chain, Immunoglobulin alpha-1 light chain, ... Authors: Eisenmesser, E.Z, Zheng, H. Deposit date: 2020-06-23 Release date: 2021-01-20 Method: ELECTRON MICROSCOPY (4 Å) Cite: Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease. Nat Commun, 11, 2020
6XRE	Structure of the p53/RNA polymerase II assembly Descriptor: Cellular tumor antigen p53, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11-a, ... Authors: Liou, S.-H, Singh, S, Singer, R.H, Coleman, R.A, Liu, W. Deposit date: 2020-07-12 Release date: 2021-03-24 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structure of the p53/RNA polymerase II assembly. Commun Biol, 4, 2021
4LO9	Human p53 Core Domain Mutant N235K Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Wallentine, B.D, Wang, Y, Luecke, H. Deposit date: 2013-07-12 Release date: 2013-07-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue. Acta Crystallogr.,Sect.D, 69, 2013
3Q01	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011
3IGL	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1) Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ... Authors: Kitayner, M, Suad, O, Rozenberg, H, Shakked, Z. Deposit date: 2009-07-28 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nat.Struct.Mol.Biol., 17, 2010
3KMD	Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer Descriptor: 5'-D(*GP*GP*GP*CP*AP*TP*GP*CP*CP*TP*AP*GP*GP*CP*AP*TP*GP*CP*C)-3', Cellular tumor antigen p53, ZINC ION Authors: Chen, Y, Dey, R, Chen, L. Deposit date: 2009-11-10 Release date: 2010-02-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure, 18, 2010
3KZ8	Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3) Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), IODIDE ION, ... Authors: Rozenberg, H, Suad, O, Shakked, Z. Deposit date: 2009-12-08 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nat.Struct.Mol.Biol., 17, 2010
4MZR	Crystal structure of a polypeptide p53 mutant bound to DNA Descriptor: Cellular tumor antigen p53, ZINC ION, consensus DNA anti-sense strand, ... Authors: Emamzadah, S.T, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D. Deposit date: 2013-09-30 Release date: 2014-01-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426, 2014
1AB9	CRYSTAL STRUCTURE OF BOVINE GAMMA-CHYMOTRYPSIN Descriptor: GAMMA-CHYMOTRYPSIN, PENTAPEPTIDE (TPGVY), SULFATE ION Authors: Sugio, S, Kashima, A, Inoue, Y, Maeda, I, Nose, T, Shimohigashi, Y. Deposit date: 1997-02-05 Release date: 1997-08-20 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (1.6 Å) Cite: X-ray crystal structure of a dipeptide-chymotrypsin complex in an inhibitory interaction. Eur.J.Biochem., 255, 1998
1AFQ	CRYSTAL STRUCTURE OF BOVINE GAMMA-CHYMOTRYPSIN COMPLEXED WITH A SYNTHETIC INHIBITOR Descriptor: BOVINE GAMMA-CHYMOTRYPSIN, D-leucyl-N-(4-fluorobenzyl)-L-phenylalaninamide, SULFATE ION Authors: Sugio, S, Kashima, A, Inoue, Y, Maeda, I, Nose, T, Shimohigashi, Y. Deposit date: 1997-03-12 Release date: 1997-09-17 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (1.8 Å) Cite: X-ray crystal structure of a dipeptide-chymotrypsin complex in an inhibitory interaction. Eur.J.Biochem., 255, 1998
4MZI	Crystal structure of a human mutant p53 Descriptor: Cellular tumor antigen p53, ZINC ION Authors: Emamzadah, S, Tropia, L, Vincenti, I, Falquet, B, Halazonetis, T.D. Deposit date: 2013-09-30 Release date: 2014-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. J.Mol.Biol., 426, 2014
3Q05	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011
3Q06	An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity Descriptor: Cellular tumor antigen p53, DNA (26-MER), ZINC ION Authors: Petty, T.J, Halazonetis, T.D. Deposit date: 2010-12-15 Release date: 2011-05-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30, 2011
8SKU	Structure of human SIgA1 in complex with human CD89 (FcaR1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... Authors: Liu, Q, Stadtmueller, B.M. Deposit date: 2023-04-20 Release date: 2023-10-25 Last modified: 2023-11-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions. Nat Commun, 14, 2023
8SKV	Structure of human SIgA1 in complex with Streptococcus pyogenes protein M4 (Arp4) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgA receptor, ... Authors: Liu, Q, Stadtmueller, B.M. Deposit date: 2023-04-20 Release date: 2023-10-25 Last modified: 2023-11-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions. Nat Commun, 14, 2023
5GCH	CHEMISTRY OF CAGED ENZYMES /II$. PHOTOACTIVATION OF INHIBITED CHYMOTRYPSIN Descriptor: GAMMA-CHYMOTRYPSIN A Authors: Stoddard, B.L, Ringe, D, Petsko, G.A. Deposit date: 1989-09-25 Release date: 1990-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Photolysis and deacylation of inhibited chymotrypsin. Biochemistry, 29, 1990
5HJ0	Crystal Structure of Mis18 'Yippee-like' Domain Descriptor: Kinetochore protein mis18, ZINC ION Authors: Medina-Pritchard, B, Subramanian, L, Allshire, R, Arockia Jeyaprakash, A. Deposit date: 2016-01-12 Release date: 2016-03-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. Embo Rep., 17, 2016
3BYK	Crystal structure of B. subtilis levansucrase mutant D247A Descriptor: CALCIUM ION, Levansucrase Authors: Futterer, K, Meng, G. Deposit date: 2008-01-16 Release date: 2008-02-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase To be Published
3BYN	Crystal structure of B. subtilis levansucrase mutant E342A bound to raffinose Descriptor: CALCIUM ION, Levansucrase, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose-(1-2)-beta-D-fructofuranose Authors: Futterer, K, Meng, G. Deposit date: 2008-01-16 Release date: 2008-02-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase To be Published
3BYJ	Crystal structure of B. subtilis levansucrase mutant D86A Descriptor: CALCIUM ION, Levansucrase Authors: Futterer, K, Meng, G. Deposit date: 2008-01-16 Release date: 2008-02-12 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Donor substrate recognition in the raffinose-bound E342A mutant of fructosyltransferase Bacillus subtilis levansucrase To be Published
7QIR	CRYSTAL STRUCTURE OF THE P1 monofluorethylglycine(MfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... Authors: Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. Deposit date: 2021-12-15 Release date: 2022-03-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
7QIS	CRYSTAL STRUCTURE OF THE P1 difluoroethylglycine (DfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... Authors: Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. Deposit date: 2021-12-15 Release date: 2022-03-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022
7QIT	CRYSTAL STRUCTURE OF THE P1 trifluoroethylglycine (TfeGly) BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX Descriptor: Chymotrypsin A chain A, Chymotrypsin A chain B, Chymotrypsin A chain C, ... Authors: Dimos, N, Leppkes, J, Koksch, B, Wahl, M.C, Loll, B. Deposit date: 2021-12-15 Release date: 2022-03-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Fluorine-induced polarity increases inhibitory activity of BPTI towards chymotrypsin. Rsc Chem Biol, 3, 2022

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