5LGY
Lysine 120-acetylated P53 DNA binding domain in a complex with the BAX response element.
Replaces: 5BUBSummary for 5LGY
Entry DOI | 10.2210/pdb5lgy/pdb |
Descriptor | Cellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... (5 entities in total) |
Functional Keywords | transcription, acetylation, transcription factor, post-translational modification, tumor suppressor, dna binding specificity, apoptosis, induced fit, genetic code expansion |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 102587.53 |
Authors | Arbely, E.,Vainer, R. (deposition date: 2016-07-08, release date: 2016-07-27, Last modification date: 2024-01-10) |
Primary citation | Vainer, R.,Cohen, S.,Shahar, A.,Zarivach, R.,Arbely, E. Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode. J.Mol.Biol., 428:3013-3025, 2016 Cited by PubMed: 27338200DOI: 10.1016/j.jmb.2016.06.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.92 Å) |
Structure validation
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