PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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8XN8	The Crystal Structure of SRC from Biortus. Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... Authors: Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. Deposit date: 2023-12-29 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The Crystal Structure of SRC from Biortus. To Be Published
8DGQ	Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide Descriptor: MALONATE ION, Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 Authors: Stiegler, A.L, Vish, K.J, Boggon, T.J. Deposit date: 2022-06-24 Release date: 2022-11-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure, 30, 2022
6MD7	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7 Descriptor: 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 Authors: Fodor, M, Stams, T. Deposit date: 2018-09-04 Release date: 2019-02-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.96 Å) Cite: 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J. Med. Chem., 62, 2019
3CD3	Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide Descriptor: CHLORIDE ION, Proto-oncogene tyrosine-protein kinase Fes/Fps, STAUROSPORINE, ... Authors: Filippakopoulos, P, Salah, E, Cooper, C, Picaud, S.S, Elkins, J.M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2008-02-26 Release date: 2008-03-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation Cell(Cambridge,Mass.), 134, 2008
3UF4	Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-10-31 Release date: 2011-12-07 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution To be published
6I5N	Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone receptor peptide Descriptor: COBALT (II) ION, Elongin-B, Elongin-C, ... Authors: Kung, W.W, Ramachandran, S, Makukhin, N, Bruno, E, Ciulli, A. Deposit date: 2018-11-14 Release date: 2019-05-29 Last modified: 2019-06-19 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat Commun, 10, 2019
2AOA	Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Growth factor receptor-bound protein 2 Authors: Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S. Deposit date: 2005-08-12 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353, 2005
4U17	Swapped dimer of the human Fyn-SH2 domain Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-15 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Swapped dimer of the human Fyn-SH2 domain To Be Published
8S0H	A fragment-based inhibitor of SHP2 Descriptor: 5-(aminomethyl)-N-(3-chloranyl-1-methyl-indol-7-yl)-1,3-dihydroisoindole-2-sulfonamide, Tyrosine-protein phosphatase non-receptor type 11 Authors: Cleasby, A, Price, A. Deposit date: 2024-02-14 Release date: 2024-03-20 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2). J.Med.Chem., 67, 2024
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1BKM	COCRYSTAL STRUCTURE OF D-AMINO ACID SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, [[O-PHOSPHONO-N-ACETYL-TYROSINYL]-GLUTAMYL-3[CYCLOHEXYLMETHYL]ALANINYL]-AMINE Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-05-02 Release date: 1997-07-07 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-Based Design of a Novel Series of Nonpeptide Ligands that Bind to the Pp60Src Sh2 Domain J.Am.Chem.Soc., 119, 1997
1O4E	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299. Descriptor: 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
4XZ0	ZAP-70-tSH2:compound-A complex Descriptor: 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 Authors: Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. Deposit date: 2015-02-03 Release date: 2015-06-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
7Z3J	Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... Authors: Pinotsis, N, Bunney, T.D, Katan, M. Deposit date: 2022-03-02 Release date: 2022-07-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. Sci Adv, 8, 2022
1O46	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395. Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Lange, G, Loenze, P, Liesum, A. Deposit date: 2003-06-15 Release date: 2004-02-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1A1A	C-SRC (SH2 DOMAIN WITH C188A MUTATION) COMPLEXED WITH ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE) Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
6JMF	Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4 Descriptor: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide, SULFATE ION, Tyrosine-protein kinase Fes/Fps Authors: Baba, D, Hanzawa, H. Deposit date: 2019-03-08 Release date: 2019-06-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. Acs Med.Chem.Lett., 10, 2019
1A09	C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine) Descriptor: ACE-FORMYL PHOSPHOTYR-GLU-(N,N-DIPENTYL AMINE), C-SRC TYROSINE KINASE Authors: Shewchuk, L, Jordan, S. Deposit date: 1997-12-10 Release date: 1998-04-08 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study. Biochemistry, 36, 1997
2HDV	Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform Authors: Hu, J, Hubbard, S.R. Deposit date: 2006-06-20 Release date: 2006-08-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS. J.Mol.Biol., 361, 2006
6WO2	Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl Descriptor: ACE-PTR-02K-ASN-U67, CALCIUM ION, Growth factor receptor-bound protein 2, ... Authors: Martin, S.F, Clements, J.H. Deposit date: 2020-04-24 Release date: 2020-09-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions. Eur.J.Med.Chem., 208, 2020
2HMH	Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3 Authors: Bergamin, E, Wu, J, Hubbard, S.R. Deposit date: 2006-07-11 Release date: 2006-08-15 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure, 14, 2006
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide Authors: Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor Authors: Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. Deposit date: 2001-09-13 Release date: 2002-03-13 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002

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