PDB: 47720 resultsInfo pagesStatus searchChemie searchBIRD

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6P39	Crystal Structure Analysis of TAF1 Bromodomain Descriptor: 3-methoxy-4-{[(6aR)-5-methyl-6-oxo-6,6a,7,8,9,10-hexahydro-5H-dipyrido[1,2-a:3',2'-e]pyrazin-2-yl]amino}-N-(1-methylpiperidin-4-yl)benzamide, Transcription initiation factor TFIID subunit 1 Authors: Seo, H.-S, Dhe-Paganon, S. Deposit date: 2019-05-23 Release date: 2020-05-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.941 Å) Cite: Crystal Structure Analysis of TAF1 Bromodomain To Be Published
8TPU	Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Anton, L, Cheng, W, Zhu, X, Ho, C.M. Deposit date: 2023-08-05 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Divergent translational landscape reflects adaptation to biased codon usage in malaria parasites To Be Published
3S9Y	Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP Descriptor: 6-amino-5-fluorouridine 5'-(dihydrogen phosphate), DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ... Authors: Liu, Y, Kotra, L.P, Pai, E.F. Deposit date: 2011-06-02 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
3S79	Human placental aromatase cytochrome P450 (CYP19A1) refined at 2.75 angstrom Descriptor: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 19A1, PHOSPHATE ION, ... Authors: Ghosh, D. Deposit date: 2011-05-26 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Novel aromatase inhibitors by structure-guided design. J.Med.Chem., 55, 2012
3SA7	Crystal structure of wild-type HIV-1 protease in complex with AF55 Descriptor: N~2~-acetyl-N-[(2S,3R)-4-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-L-leucinamide, PHOSPHATE ION, Protease Authors: Schiffer, C.A, Nalam, M.N.L. Deposit date: 2011-06-02 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
3SDW	Crystal structure of a ribose-5-phosphate isomerase B RpiB from Coccidioides immitis bound to phosphate Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-06-09 Release date: 2011-06-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. Bmc Struct.Biol., 11, 2011
6OZL	Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 2 min soak in Mn2+ Descriptor: DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3'), Endonuclease V, GLYCEROL, ... Authors: Samara, N.L, Yang, W. Deposit date: 2019-05-15 Release date: 2019-09-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase. Mol.Cell, 76, 2019
3SDK	Structure of yeast 20S open-gate proteasome with Compound 34 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, N-[(2S)-3-(3-tert-butyl-1,2,4-oxadiazol-5-yl)-1-({(2S)-1-[(4-methylbenzyl)amino]-1-oxo-4-phenylbutan-2-yl}amino)-1-oxopropan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide, ... Authors: Sintchak, M.D. Deposit date: 2011-06-09 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorg.Med.Chem.Lett., 20, 2010
4OSR	Crystal structure of the S505K mutant of TAL effector dHax3 Descriptor: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*GP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 Authors: Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. Deposit date: 2014-02-13 Release date: 2014-05-28 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.944 Å) Cite: Revisiting the TALE repeat Protein Cell, 5, 2014
6P1Z	Bacteriophage phiKZ gp163.1 PAAR repeat protein in complex with the C-terminal part of the T4 gp5 beta-helical domain Descriptor: 9-OCTADECENOIC ACID, Baseplate central spike complex protein gp5, MAGNESIUM ION, ... Authors: Buth, S.A, Shneider, M.M, Leiman, P.G. Deposit date: 2019-05-20 Release date: 2020-05-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Bacteriophage phiKZ gp163.1 PAAR repeat protein in complex with the C-terminal part of the T4 gp5 beta-helical domain To Be Published
8VK3	Structure of mouse RyR1 in complex with S100A1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Protein S100A1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-01-24 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. Proc.Natl.Acad.Sci.USA, 121, 2024
3SNH	Crystal structure of nucleotide-free human dynamin1 Descriptor: Dynamin-1 Authors: Faelber, K, Daumke, O. Deposit date: 2011-06-29 Release date: 2011-09-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Crystal structure of nucleotide-free dynamin. Nature, 477, 2011
8W4J	Cryo-EM structure of the KLHL22 E3 ligase bound to human glutamate dehydrogenase I Descriptor: Glutamate dehydrogenase 1, mitochondrial, Kelch-like protein 22 Authors: Su, M.-Y, Su, M.-Y. Deposit date: 2023-08-24 Release date: 2023-11-01 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.06 Å) Cite: Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
6PB4	The E. coli class-II CAP-dependent transcription activation complex with de novo RNA transcript at the state 2 Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W. Deposit date: 2019-06-13 Release date: 2020-03-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.35 Å) Cite: Visualization of two architectures in class-II CAP-dependent transcription activation Plos Biol., 18, 2020
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXF	Structure of PKA phosphorylated human RyR2-R420W in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
3S91	Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1 Descriptor: (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Bromodomain-containing protein 3, ISOPROPYL ALCOHOL Authors: Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2011-05-31 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1 To be Published
8UXL	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
3SA8	Crystal structure of wild-type HIV-1 protease in complex with KB83 Descriptor: 3-hydroxy-N-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]benzamide, ACETATE ION, PHOSPHATE ION, ... Authors: Schiffer, C.A, Nalam, M.N.L. Deposit date: 2011-06-02 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published
8UXM	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXI	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
6OZK	Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after 68h soak in Ca2+ Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3'), ... Authors: Samara, N.L, Yang, W. Deposit date: 2019-05-15 Release date: 2019-09-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.104 Å) Cite: Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase. Mol.Cell, 76, 2019

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