2OLN
| NikD, an unusual amino acid oxidase essential for nikkomycin biosynthesis: closed form at 1.15 A resolution | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, PYRIDINE-2-CARBOXYLIC ACID, SODIUM ION, ... | Authors: | Carrell, C.J, Bruckner, R.C, Venci, D, Zhao, G, Jorns, M.S, Mathews, F.S. | Deposit date: | 2007-01-19 | Release date: | 2007-07-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | NikD, an unusual amino acid oxidase essential for nikkomycin biosynthesis: structures of closed and open forms at 1.15 and 1.90 A resolution Structure, 15, 2007
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4QZ0
| yCP beta5-M45V mutant in complex with the epoxyketone inhibitor ONX 0914 | Descriptor: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-27 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QV1
| yCP beta5-M45A mutant | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-14 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4QW1
| yCP beta5-A50V mutant in complex with bortezomib | Descriptor: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-16 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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4R2G
| Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Garces, F, Wilson, I.A. | Deposit date: | 2014-08-11 | Release date: | 2014-10-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.283 Å) | Cite: | Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies. Cell(Cambridge,Mass.), 159, 2014
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7OVO
| Heterodimeric murine tRNA-guanine transglycosylase in complex with queuine | Descriptor: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Queuine tRNA-ribosyltransferase accessory subunit 2, ... | Authors: | Sebastiani, M, Heine, A, Reuter, K. | Deposit date: | 2021-06-15 | Release date: | 2022-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Acs Chem.Biol., 17, 2022
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4QWX
| yCP in complex with the epoxyketone inhibitor ONX 0914 | Descriptor: | 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-17 | Release date: | 2015-02-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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6XLN
| Cryo-EM structure of E. coli RNAP-DNA elongation complex 2 (RDe2) in EcmrR-dependent transcription | Descriptor: | 9-nt RNA transcript, CHAPSO, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Yang, Y, Liu, C, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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8GS5
| Crystal structure of a constitutively active mutant of human IDH3 holoenzyme in apo form | Descriptor: | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit gamma, ... | Authors: | Sun, P, Chen, X, Ding, J. | Deposit date: | 2022-09-04 | Release date: | 2022-11-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (4.486 Å) | Cite: | Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction. J.Biol.Chem., 298, 2022
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6XLM
| Cryo-EM structure of E.coli RNAP-DNA elongation complex 1 (RDe1) in EcmrR-dependent transcription | Descriptor: | 9-nt RNA transcript, CHAPSO, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Yang, Y, Liu, C, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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6XH7
| CueR-TAC without RNA | Descriptor: | COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-06-18 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
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2YPO
| 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site | Descriptor: | GLYCEROL, MANGANESE (II) ION, PHENYLALANINE, ... | Authors: | Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J. | Deposit date: | 2012-10-31 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis. J.Mol.Biol., 425, 2013
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6XLL
| Cryo-EM structure of E. coli RNAP-promoter initial transcribing complex with 5-nt RNA transcript (RPitc-5nt) | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yang, Y, Liu, C, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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6XL9
| Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 3-nt RNA transcript (EcmrR-RPitc-3nt) | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Yang, Y, Liu, C, Shi, W, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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6XH8
| CueR-transcription activation complex with RNA transcript | Descriptor: | COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-06-18 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
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4QZZ
| yCP in complex with Omuralide | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Omuralide, ... | Authors: | Huber, E.M, Heinemeyer, W, Groll, M. | Deposit date: | 2014-07-29 | Release date: | 2015-02-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23, 2015
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7OR1
| Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 1 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2021-06-04 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60 TO BE PUBLISHED
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6XLJ
| Cryo-EM structure of EcmrR-RNAP-promoter initial transcribing complex with 4-nt RNA transcript (EcmrR-RPitc-4nt) | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yang, Y, Liu, C, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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7OXN
| Crystal Structure of TAP01 in complex with cyclised amyloid beta peptide | Descriptor: | 1,2-ETHANEDIOL, Amyloid-beta precursor protein, TAP01 family antibody heavy chain, ... | Authors: | Hall, G, Cowan, R, Carr, M.D. | Deposit date: | 2021-06-22 | Release date: | 2022-06-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease. Mol Psychiatry, 27, 2022
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6XL5
| Cryo-EM structure of EcmrR-RNAP-promoter open complex (EcmrR-RPo) | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yang, Y, Liu, C, Liu, B. | Deposit date: | 2020-06-28 | Release date: | 2021-04-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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8GRB
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7OV9
| Heterodimeric tRNA-Guanine Transglycosylase from mouse, apo-structure | Descriptor: | HEXAETHYLENE GLYCOL, Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase catalytic subunit 1, ... | Authors: | Sebastiani, M, Heine, A, Reuter, K. | Deposit date: | 2021-06-14 | Release date: | 2022-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Acs Chem.Biol., 17, 2022
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5EJ9
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 2 min and isochorismate for 13 min | Descriptor: | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, GLYCEROL, ... | Authors: | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | Deposit date: | 2015-11-01 | Release date: | 2016-06-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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2YQ6
| Structure of Bcl-xL bound to BimSAHB | Descriptor: | BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL | Authors: | Smith, B.J, Czabotar, P.E. | Deposit date: | 2012-11-06 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
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7OR0
| Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60, conformation 2 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Grieben, M, Pike, A.C.W, Saward, B.G, Wang, D, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Schofield, C.J, Carpenter, E.P. | Deposit date: | 2021-06-04 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Cryo-EM structure of the human TRPA1 ion channel in complex with the antagonist 3-60 To Be Published
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