8GRB

Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3

Summary for 8GRB

• Entry DOI: 10.2210/pdb8grb/pdb
• Descriptor: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (2 entities in total)
• Functional Keywords: isocitrate dehydrogenase, nad-dependent idh, assembly, allosteric regulation, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 606217.25

Authors

Sun, P.,Chen, X.,Ding, J. (deposition date: 2022-09-01, release date: 2022-12-07, Last modification date: 2022-12-21)

• Primary citation: Chen, X.,Sun, P.,Liu, Y.,Shen, S.,Ma, T.,Ding, J.; Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.; J.Biol.Chem., 298:102695-102695, 2022; PubMed: 36375638; DOI: 10.1016/j.jbc.2022.102695

Experimental method

X-RAY DIFFRACTION (2.848 Å)