8YKW
 
 | | Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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8YKV
 | | Cryo-EM structure of succinate receptor SUCR1 bound to compound 31 | | Descriptor: | (2~{S})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid, Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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8YKX
 | | Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid | | Descriptor: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | Deposit date: | 2024-03-05 | | Release date: | 2024-05-29 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 34, 2024
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8YUV
 | | Cryo-EM structure of the immepip-bound H3R-Gi complex | | Descriptor: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
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8YUT
 | | Cryo-EM structure of the amthamine-bound H2R-Gs complex | | Descriptor: | 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
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8YUU
 | | Cryo-EM structure of the histamine-bound H3R-Gi complex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | | Deposit date: | 2024-03-27 | | Release date: | 2024-06-05 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
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8YFS
 | | MRGPRE-Gq-scFv16-complex | | Descriptor: | (~{E})-3-(2-methoxyphenyl)prop-2-enal, Gq protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhong, Y.N. | | Deposit date: | 2024-02-25 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MRGPRE-Gq-scFv16-complex
To Be Published
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8YU7
 | | Cryo-EM structure of CXCR4 tetramer | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL | | Authors: | Liu, A, Liu, Y. | | Deposit date: | 2024-03-26 | | Release date: | 2025-03-05 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis of CXCR4 assembly and regulation.
Cell Rep, 44, 2025
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8YYX
 | | Cryo-EM structure of OXGR1 bound to leukotriene E4 and Gq proteins | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 2-oxoglutarate receptor 1, CHOLESTEROL, ... | | Authors: | Liu, A, Liu, Y. | | Deposit date: | 2024-04-04 | | Release date: | 2025-04-09 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Cryo-EM structure of OXGR1 bound to leukotriene E4 and Gq proteins
To Be Published
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8YH0
 | | A3R-Gi complex bound to NECA | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HA tag,Adenosine receptor A3,LgBiT,eGFP chimera, ... | | Authors: | Oshima, H.S, Shihoya, W, Nureki, O. | | Deposit date: | 2024-02-27 | | Release date: | 2024-11-06 | | Last modified: | 2024-11-27 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural insights into the agonist selectivity of the adenosine A 3 receptor.
Nat Commun, 15, 2024
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8YH5
 | | A3R-Gi complex bound to i6A | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-1 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hemagglutinin,Adenosine receptor A3,GFP chimera, ... | | Authors: | Oshima, H.S, Shihoya, W, Nureki, O. | | Deposit date: | 2024-02-27 | | Release date: | 2024-11-06 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Structural insights into the agonist selectivity of the adenosine A 3 receptor.
Nat Commun, 15, 2024
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8XXV
 | | Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | Deposit date: | 2024-01-19 | | Release date: | 2024-12-04 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8XXU
 | | Cryo-EM Structure of the Prostaglandin D2 Receptor 2 Coupled to G Protein | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | Deposit date: | 2024-01-19 | | Release date: | 2024-12-04 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8Y69
 | | LGR4-RSPO2-ZNRF3 (2:2:2) | | Descriptor: | CHOLESTEROL, E3 ubiquitin-protein ligase ZNRF3, Leucine-rich repeat-containing G-protein coupled receptor 4, ... | | Authors: | Wang, L, Geng, Y. | | Deposit date: | 2024-02-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/ beta-catenin signaling.
Nat Commun, 16, 2025
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8XIQ
 | | Structure of L796778-SSTR3 G protein complex | | Descriptor: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8YYW
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8Z3M
 | | Cryo-EM structure of the hGPR4-Gq complex in pH6.5 | | Descriptor: | Engineered G-alpha-q subunit, G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhong, Y.N, Guo, L.L, Yang, F, Sun, J.P. | | Deposit date: | 2024-04-15 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structure of the hGPR4-Gq complex in pH6.5
To Be Published
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8Z65
 | | Cryo-EM structure of the hGPR4-Gs complex in pH7.2 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhong, Y.N, Guo, L.L. | | Deposit date: | 2024-04-18 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Cryo-EM structure of the hGPR4-Gs complex in pH7.2
To Be Published
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8Z5H
 | | Cryo-EM structure of the hGPR68-Gs complex in pH6.0 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Zhong, Y.N, Guo, L.L, Yang, F, Sun, J.P. | | Deposit date: | 2024-04-18 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of the hGPR68-Gs complex in pH6.0
To Be Published
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8Z3Q
 | | Cryo-EM structure of the hGPR4-Gs complex in pH7.6 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhong, Y.N, Guo, L.L, Yang, F, Sun, J.P. | | Deposit date: | 2024-04-15 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Cryo-EM structure of the hGPR4-Gs complex in pH7.6
To Be Published
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8Z68
 | | Cryo-EM structure of the hGPR68-Gs complex in pH6.8 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Zhong, Y.N, Guo, L.L, Yang, F, Sun, J.P. | | Deposit date: | 2024-04-18 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Cryo-EM structure of the hGPR68-Gs complex in pH6.8
To Be Published
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8Z3Y
 | | Cryo-EM structure of of hGPR4-Gs complex in pH6.8 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhong, Y.N, Guo, L.L. | | Deposit date: | 2024-04-16 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of the receptor of hGPR4-Gs complex in pH6.8
To Be Published
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8XIO
 | | Structure of L797591-SSTR1 G protein complex | | Descriptor: | (2~{S})-~{N}-[(4~{S})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide, G-alpha-i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8XIR
 | | Structure of pasireotide-SSTR3 G protein complex | | Descriptor: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8XIP
 | | Structure of Pasireotide-SSTR1 G protein complex | | Descriptor: | 004-DTR-LYS-TY5-PHE-A1D5E, G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | | Deposit date: | 2023-12-19 | | Release date: | 2024-07-03 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3.
Proc.Natl.Acad.Sci.USA, 121, 2024
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