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5OI5	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION Authors: Ruff, M, Benarous, R. Deposit date: 2017-07-18 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OI3	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 Descriptor: Integrase, MAGNESIUM ION Authors: Ruff, M, Benarous, R. Deposit date: 2017-07-18 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OIA	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ... Authors: Ruff, M, Benarous, R. Deposit date: 2017-07-18 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
5OI2	Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1 Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION, ... Authors: Ruff, M, Benarous, R. Deposit date: 2017-07-18 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293, 2018
2PSG	REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION Descriptor: PEPSINOGEN Authors: James, M.N.G, Sielecki, A.R. Deposit date: 1991-01-23 Release date: 1992-10-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Refined structure of porcine pepsinogen at 1.8 A resolution. J.Mol.Biol., 219, 1991
1QJZ	Three Dimensional Structure of Physalis Mottle Virus : Implications for the Viral Assembly Descriptor: COAT PROTEIN Authors: Krishna, S.S, Hiremath, C.N, Munshi, S.K, Prahadeeswaran, D, Sastri, M, Savithri, H.S, Murthy, M.R.N. Deposit date: 1999-07-07 Release date: 1999-07-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Three Dimensional Structure of Physalis Movirus: Implications for the Viral Assembly J.Mol.Biol., 289, 1999
8RND	Cathepsin S in complex with NNPI-C10 inhibitor Descriptor: 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ... Authors: Petruzzella, A, Lau, K, Pojer, F, Oricchio, E. Deposit date: 2024-01-09 Release date: 2024-06-05 Last modified: 2024-06-12 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins. Nat.Chem.Biol., 2024
8SXM	NMR structure of the ZNF750 zinc finger domain, Z* Descriptor: ZINC ION, Zinc finger protein 750 Authors: Rua, A.J, Alexandrescu, A.T. Deposit date: 2023-05-22 Release date: 2023-08-23 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750. J Struct Biol X, 8, 2023
8TDO	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology Descriptor: Transthyretin Authors: Nguyen, B.A, Singh, V, Saelices, L. Deposit date: 2023-07-04 Release date: 2023-12-13 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8TDN	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology Descriptor: Transthyretin Authors: Nguyen, B.A, Singh, V, Saelices, L. Deposit date: 2023-07-04 Release date: 2023-12-13 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
5E5K	Joint X-ray/neutron structure of HIV-1 protease triple mutant (V32I,I47V,V82I) with darunavir at pH 4.3 Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 protease Authors: Kovalevsky, A.Y, Das, A. Deposit date: 2015-10-08 Release date: 2016-05-04 Last modified: 2024-03-06 Method: NEUTRON DIFFRACTION (1.75 Å), X-RAY DIFFRACTION Cite: Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site. Angew.Chem.Int.Ed.Engl., 55, 2016
8Q8S	Tau - AD-THF Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-18 Release date: 2023-09-20 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8Z	Tau - CTE-MIA7 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-19 Release date: 2023-09-20 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9A	Tau - CTE-MIA11 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-20 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8E	Tau - AD-LIA4 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-18 Release date: 2023-09-20 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q8X	Tau - CTE-MIA5 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-19 Release date: 2023-09-20 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8Q9B	Tau - CTE-MIA13 (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. Deposit date: 2023-08-20 Release date: 2023-09-20 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
8QJJ	CTE type II (tau intermediate amyloid) Descriptor: Isoform Tau-D of Microtubule-associated protein tau Authors: Lovestam, S, Scheres, S.H.W. Deposit date: 2023-09-13 Release date: 2023-10-18 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
5FHL	Extensive amphimorphism in DNA: Three stable conformations for the decadeoxynucleotide d(GCATGCATGC) Descriptor: DNA (5'-D(*GP*CP*AP*TP*GP*CP*AP*TP*GP*C)-3') Authors: Thirugnanasambandam, A, Karthik, S, Gautham, N. Deposit date: 2015-12-22 Release date: 2016-06-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.791 Å) Cite: DNA polymorphism in crystals: three stable conformations for the decadeoxynucleotide d(GCATGCATGC). Acta Crystallogr D Struct Biol, 72, 2016
5HIB	EGFR kinase domain mutant "TMLR" with a pyrazolopyrimidine inhibitor Descriptor: Epidermal growth factor receptor, N-tert-butyl-5-{[(1-methyl-1H-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide Authors: Eigenbrot, C, Yu, C. Deposit date: 2016-01-11 Release date: 2016-04-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5HIC	EGFR kinase domain mutant "TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor Descriptor: Epidermal growth factor receptor, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION Authors: Eigenbrot, C, Yu, C. Deposit date: 2016-01-11 Release date: 2016-04-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell, 29, 2016
5HCH	X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair Descriptor: (6S)-2,6-anhydro-1-deoxy-6-(2-{[(S)-hydroxy(oxido)-lambda~5~-phosphanyl]oxy}ethyl)-D-galactitol, CALCIUM ION, DNA (5'-D(*CP*GP*CP*AP*TP*TP*(DF)P*TP*AP*TP*CP*GP*C)-3'), ... Authors: Roethlisberger, P, Istrate, A, Marcaida Lopez, M.J, Visini, R, Stocker, A, Leumann, C.J. Deposit date: 2016-01-04 Release date: 2016-03-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chem.Commun.(Camb.), 52, 2016
5FHJ	Extensive amphimorphism in DNA: Three stable conformations for the decadeoxynucleotide d(GCATGCATGC) Descriptor: COBALT (II) ION, DNA (5'-D(*GP*CP*AP*TP*GP*CP*AP*TP*GP*C)-3') Authors: Thirugnanasambandam, A, Karthik, S, Gautham, N. Deposit date: 2015-12-22 Release date: 2016-06-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.68 Å) Cite: DNA polymorphism in crystals: three stable conformations for the decadeoxynucleotide d(GCATGCATGC). Acta Crystallogr D Struct Biol, 72, 2016
8AH7	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P212121 at pH 4.0 Descriptor: SULFATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas-Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.25 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
8E7E	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient Descriptor: Transthyretin Authors: Nguyen, B.A, Singh, V, Afrin, S, Saelices, L. Deposit date: 2022-08-23 Release date: 2023-08-30 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024

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