8E7E

Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient

Summary for 8E7E

• Entry DOI: 10.2210/pdb8e7e/pdb
• EMDB information: 26685
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: transthyretin, amyloidosis, systemic amyloidosis, attr, cardiac, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 5
• Total formula weight: 79394.51

Authors

Nguyen, B.A.,Singh, V.,Afrin, S.,Saelices, L. (deposition date: 2022-08-23, release date: 2023-08-30, Last modification date: 2024-03-13)

• Primary citation: Nguyen, B.A.,Singh, V.,Afrin, S.,Yakubovska, A.,Wang, L.,Ahmed, Y.,Pedretti, R.,Fernandez-Ramirez, M.D.C.,Singh, P.,Pekala, M.,Cabrera Hernandez, L.O.,Kumar, S.,Lemoff, A.,Gonzalez-Prieto, R.,Sawaya, M.R.,Eisenberg, D.S.,Benson, M.D.,Saelices, L.; Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy; Nat Commun, 15:581-, 2024; DOI: 10.1038/s41467-024-44820-3

Experimental method

ELECTRON MICROSCOPY (3.61 Å)