8TDN

Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology

Summary for 8TDN

Entry DOI	10.2210/pdb8tdn/pdb
EMDB information	26685 27323 41171
Descriptor	Transthyretin (1 entity in total)
Functional Keywords	attr, amyloidosis, cardiac fibril, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	79394.51
Authors	Nguyen, B.A.,Singh, V.,Saelices, L. (deposition date: 2023-07-04, release date: 2023-12-13, Last modification date: 2024-03-13)
Primary citation	Nguyen, B.A.,Singh, V.,Afrin, S.,Yakubovska, A.,Wang, L.,Ahmed, Y.,Pedretti, R.,Fernandez-Ramirez, M.D.C.,Singh, P.,Pekala, M.,Cabrera Hernandez, L.O.,Kumar, S.,Lemoff, A.,Gonzalez-Prieto, R.,Sawaya, M.R.,Eisenberg, D.S.,Benson, M.D.,Saelices, L. Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15:581-581, 2024 Cited by PubMed: 38233397 DOI: 10.1038/s41467-024-44820-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation