5OIA
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Summary for 5OIA
Entry DOI | 10.2210/pdb5oia/pdb |
Related | 4LH4 |
Descriptor | Pol protein, MAGNESIUM ION, (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, ... (5 entities in total) |
Functional Keywords | hiv-1, integrase, catalytic core domain, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 20637.84 |
Authors | Ruff, M.,Benarous, R. (deposition date: 2017-07-18, release date: 2018-03-07, Last modification date: 2024-01-17) |
Primary citation | Bonnard, D.,Le Rouzic, E.,Eiler, S.,Amadori, C.,Orlov, I.,Bruneau, J.M.,Brias, J.,Barbion, J.,Chevreuil, F.,Spehner, D.,Chasset, S.,Ledoussal, B.,Moreau, F.,Saib, A.,Klaholz, B.P.,Emiliani, S.,Ruff, M.,Zamborlini, A.,Benarous, R. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration. J. Biol. Chem., 293:6172-6186, 2018 Cited by PubMed: 29507092DOI: 10.1074/jbc.M117.816793 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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