8WAK
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![BU of 8wak by Molmil](/molmil-images/mine/8wak) | Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-07 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (5.47 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAR
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![BU of 8war by Molmil](/molmil-images/mine/8war) | Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS. | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | Deposit date: | 2023-09-08 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Structural visualization of transcription initiation in action. Science, 382, 2023
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7VZ4
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![BU of 7vz4 by Molmil](/molmil-images/mine/7vz4) | Cryo-EM structure of human nucleosome core particle composed of the Widom 601L DNA sequence | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Takizawa, Y, Ho, C.-H, Sato, S, Danev, R, Kurumizaka, H. | Deposit date: | 2021-11-15 | Release date: | 2023-05-17 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (1.89 Å) | Cite: | Methods for High Resolution Cryo-EM Analyses of Nucleosomes To Be Published
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7W1M
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![BU of 7w1m by Molmil](/molmil-images/mine/7w1m) | Cryo-EM structure of human cohesin-CTCF-DNA complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ... | Authors: | Shi, Z.B, Bai, X.C, Yu, H. | Deposit date: | 2021-11-19 | Release date: | 2023-05-31 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Mol.Cell, 83, 2023
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7K61
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![BU of 7k61 by Molmil](/molmil-images/mine/7k61) | Cryo-EM structure of 197bp nucleosome aided by scFv | Descriptor: | DNA (197-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Zhou, B.-R, Bai, Y. | Deposit date: | 2020-09-17 | Release date: | 2020-11-25 | Last modified: | 2021-01-20 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms. Mol.Cell, 81, 2021
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5Y0D
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![BU of 5y0d by Molmil](/molmil-images/mine/5y0d) | Crystal Structure of the human nucleosome containing the H2B E76K mutant | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | Authors: | Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. | Deposit date: | 2017-07-16 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
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8QFD
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![BU of 8qfd by Molmil](/molmil-images/mine/8qfd) | UFL1 E3 ligase bound 60S ribosome | Descriptor: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Makhlouf, L, Kulathu, Y, Zeqiraj, E. | Deposit date: | 2023-09-04 | Release date: | 2024-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature, 627, 2024
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7X39
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![BU of 7x39 by Molmil](/molmil-images/mine/7x39) | Structure of CIZ1 bound ERH | Descriptor: | Enhancer of rudimentary homolog,Cip1-interacting zinc finger protein | Authors: | Wang, X, Xu, C. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Molecular basis for the recognition of CIZ1 by ERH. Febs J., 290, 2023
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8W8F
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![BU of 8w8f by Molmil](/molmil-images/mine/8w8f) | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, DNA (36-MER), DNA (45-MER), ... | Authors: | Li, Y, Wang, Q, Xu, Y, Li, Z. | Deposit date: | 2023-09-02 | Release date: | 2024-04-10 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
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7K5X
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![BU of 7k5x by Molmil](/molmil-images/mine/7k5x) | |
7LYC
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![BU of 7lyc by Molmil](/molmil-images/mine/7lyc) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) | Descriptor: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-06-16 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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8W9D
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7LJ1
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![BU of 7lj1 by Molmil](/molmil-images/mine/7lj1) | Human Prx1-Srx Decameric Complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Forshaw, T.E, Reisz, J.A, Nelson, K.J, Gumpena, R, Lawson, J.R, Jonsson, T, Wu, H, Clodfelter, J.E, Johnson, L, Furdui, C.M, Lowther, W.T. | Deposit date: | 2021-01-28 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State. Antioxidants (Basel), 10, 2021
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6FML
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![BU of 6fml by Molmil](/molmil-images/mine/6fml) | CryoEM Structure INO80core Nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin related protein 5, ... | Authors: | Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. | Deposit date: | 2018-01-31 | Release date: | 2018-04-25 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.34 Å) | Cite: | Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
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7W9V
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![BU of 7w9v by Molmil](/molmil-images/mine/7w9v) | Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I) | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H. | Deposit date: | 2021-12-10 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. Iscience, 25, 2022
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7WTS
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![BU of 7wts by Molmil](/molmil-images/mine/7wts) | Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S13, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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8RC0
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![BU of 8rc0 by Molmil](/molmil-images/mine/8rc0) | Structure of the human 20S U5 snRNP | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Schneider, S, Galej, W.P. | Deposit date: | 2023-12-05 | Release date: | 2024-03-27 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the human 20S U5 snRNP. Nat.Struct.Mol.Biol., 31, 2024
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7K5Y
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![BU of 7k5y by Molmil](/molmil-images/mine/7k5y) | |
7K17
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![BU of 7k17 by Molmil](/molmil-images/mine/7k17) | |
7UPZ
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![BU of 7upz by Molmil](/molmil-images/mine/7upz) | Structural basis for cell type specific DNA binding of C/EBPbeta: the case of cell cycle inhibitor p15INK4b promoter | Descriptor: | CCAAT/enhancer-binding protein beta, DNA (5'-D(*AP*TP*TP*CP*TP*TP*AP*AP*GP*AP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*TP*CP*TP*TP*AP*AP*GP*AP*A)-3') | Authors: | Lountos, G.T, Cherry, S, Tropea, J.E, Wlodawer, A, Miller, M. | Deposit date: | 2022-04-18 | Release date: | 2022-11-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.487 Å) | Cite: | Structural basis for cell type specific DNA binding of C/EBP beta : The case of cell cycle inhibitor p15INK4b promoter. J.Struct.Biol., 214, 2022
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6G16
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![BU of 6g16 by Molmil](/molmil-images/mine/6g16) | Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange | Descriptor: | Histone-binding protein RBBP4, Metastasis-associated protein MTA1 | Authors: | Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R. | Deposit date: | 2018-03-20 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife, 5, 2016
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8X73
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![BU of 8x73 by Molmil](/molmil-images/mine/8x73) | Crystal structure of Peroxiredoxin I in complex with compound 19-069 | Descriptor: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8PKI
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![BU of 8pki by Molmil](/molmil-images/mine/8pki) | Cryo-EM structure of NR5A2-nucleosome complex SHL+5.5 | Descriptor: | DNA, Histone H2A, Histone H2B type 1-C/E/G, ... | Authors: | Kobayashi, W, Sappler, A, Bollschweiler, D, Kummecke, M, Basquin, J, Arslantas, E, Ruangroengkulrith, S, Hornberger, R, Duderstadt, K, Tachibana, K. | Deposit date: | 2023-06-26 | Release date: | 2024-02-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition. Nat.Struct.Mol.Biol., 31, 2024
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8PKJ
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![BU of 8pkj by Molmil](/molmil-images/mine/8pkj) | Cryo-EM structure of the nucleosome containing Nr5a2 motif at SHL+5.5 | Descriptor: | DNA, Histone H2A, Histone H2B, ... | Authors: | Kobayashi, W, Sappler, A, Bollschweiler, D, Kummecke, M, Basquin, J, Arslantas, E, Ruangroengkulrith, S, Hornberger, R, Duderstadt, K, Tachibana, K. | Deposit date: | 2023-06-26 | Release date: | 2024-02-28 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition. Nat.Struct.Mol.Biol., 31, 2024
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8X71
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![BU of 8x71 by Molmil](/molmil-images/mine/8x71) | Crystal structure of Peroxiredoxin I in complex with compound 19-064 | Descriptor: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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