PDB: 222624 resultsInfo pagesStatus searchChemie searchBIRD

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2PFV	S. cerevisiae Exo70 with additional residues to 2.1 Angrstrom resolution Descriptor: Exocyst complex component EXO70 Authors: Moore, B.A, Robinson, H.H, Xu, Z. Deposit date: 2007-04-05 Release date: 2007-05-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. J.Mol.Biol., 371, 2007
4JDS	SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine Descriptor: Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ... Authors: Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) Deposit date: 2013-02-25 Release date: 2013-03-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine to be published
4JEA	Crystal structure of an engineered Zn-RIDC1 construct with four interfacial disulfide bonds Descriptor: PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ZINC ION, ... Authors: Tezcan, F.A, Medina-Morales, A.M, Perez, A, Brodin, J.D. Deposit date: 2013-02-26 Release date: 2013-08-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.22 Å) Cite: In Vitro and Cellular Self-Assembly of a Zn-Binding Protein Cryptand via Templated Disulfide Bonds. J.Am.Chem.Soc., 135, 2013
3EJS	Golgi alpha-Mannosidase II in complex with 5-substituted swainsonine analog: (5S)-5-[2'-(4-tert-butylphenyl)ethyl]-swainsonine Descriptor: (1S,2R,5S,8R,8aR)-5-[2-(4-tert-butylphenyl)ethyl]octahydroindolizine-1,2,8-triol, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Kuntz, D.A, Shea, K, Rose, D.R. Deposit date: 2008-09-18 Release date: 2009-10-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. Chembiochem, 11, 2010
4JFL	Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one Descriptor: 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F. Deposit date: 2013-02-28 Release date: 2013-08-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J.Med.Chem., 56, 2013
3PV5	Structure of Legionella fallonii DegQ (N189G/P190G variant) Descriptor: DegQ Authors: Wrase, R, Scott, H, Hilgenfeld, R, Hansen, G. Deposit date: 2010-12-06 Release date: 2011-06-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies. Proc.Natl.Acad.Sci.USA, 108, 2011
3E8V	Crystal structure of a possible transglutaminase-family protein proteolytic fragment from Bacteroides fragilis Descriptor: Possible transglutaminase-family protein, UNKNOWN LIGAND Authors: Bonanno, J.B, Rutter, M, Bain, K.T, Hu, S, Romero, R, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2008-08-20 Release date: 2008-09-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of a possible transglutaminase-family protein proteolytic fragment from Bacteroides fragilis To be Published
3PVW	Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A) Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Thal, D.M, Tesmer, J.J. Deposit date: 2010-12-07 Release date: 2011-06-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol.Pharmacol., 80, 2011
4JGS	Crystal structure of the xmrv tm retroviral fusion core Descriptor: CHLORIDE ION, MLV-related proviral Env polyprotein Authors: Cook, J.D, Aydin, H, Lee, J.E. Deposit date: 2013-03-02 Release date: 2013-10-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of Beta- and gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry. J.Virol., 88, 2014
3E93	Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor Descriptor: 4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin-4-yl-1,2-benzisoxazol-6-yl)benzamide, GLYCEROL, Mitogen-activated protein kinase 14 Authors: Somers, D.O, Patel, S. Deposit date: 2008-08-21 Release date: 2008-09-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Kinase array design, back to front: Biaryl amides Bioorg.Med.Chem.Lett., 18, 2008
3PNM	Crystal Structure of E.coli Dha kinase DhaK (H56A) Descriptor: PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK Authors: Shi, R, McDonald, L, Matte, A, Cygler, M, Ekiel, I, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) Deposit date: 2010-11-19 Release date: 2011-01-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proc.Natl.Acad.Sci.USA, 108, 2011
2PQU	Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna Descriptor: 12-mer C-rich strand of human telomeric DNA, Poly(rC)-binding protein 2 Authors: James, T.L, Lee, J. Deposit date: 2007-05-02 Release date: 2007-06-12 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (2.12 Å) Cite: X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2. Rna, 13, 2007
3PX4	Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*AP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ... Authors: Wang, W, Beese, L.S. Deposit date: 2010-12-09 Release date: 2011-10-19 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.582 Å) Cite: Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis. Proc.Natl.Acad.Sci.USA, 108, 2011
3E46	Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A mutant Descriptor: CALCIUM ION, Ubiquitin-conjugating enzyme E2-25 kDa Authors: Hughes, R.C, Wilson, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D. Deposit date: 2008-08-09 Release date: 2008-08-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). Acta Crystallogr.,Sect.F, 65, 2009
2ES4	Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase Descriptor: CALCIUM ION, IODIDE ION, Lipase, ... Authors: Pauwels, K, Wyns, L, Tommassen, J, Savvides, S.N, Van Gelder, P. Deposit date: 2005-10-25 Release date: 2006-03-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of a membrane-based steric chaperone in complex with its lipase substrate. Nat.Struct.Mol.Biol., 13, 2006
2GXB	Crystal Structure of The Za Domain bound to Z-RNA Descriptor: 5'-R(P*(DU)P*CP*GP*CP*GP*CP*G)-3', Double-stranded RNA-specific adenosine deaminase, SODIUM ION Authors: Athanasiadis, A, Placido, D, Rich, A. Deposit date: 2006-05-08 Release date: 2007-05-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.25 Å) Cite: A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1. Structure, 15, 2007
4M11	Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, ... Authors: Xu, S, Banerjee, S, Hermanson, D.J, Marnett, L.J. Deposit date: 2013-08-02 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J.Biol.Chem., 289, 2014
2GYY	Structure of aspartate semialdehyde dehydrogenase (ASADH) from Streptococcus pneumoniae Descriptor: Aspartate beta-semialdehyde dehydrogenase Authors: Faehnle, C.R, Le Coq, J, Liu, X, Viola, R.E. Deposit date: 2006-05-10 Release date: 2006-08-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria. J.Biol.Chem., 281, 2006
4J5U	X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith Descriptor: Serine hydroxymethyltransferase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-02-10 Release date: 2013-03-13 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith TO BE PUBLISHED
4M2U	Carbonic Anhydrase II in complex with Dorzolamide Descriptor: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION Authors: Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, Mckenna, R. Deposit date: 2013-08-05 Release date: 2013-11-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.999 Å) Cite: Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21, 2013
4JIM	Native Crystal Structure of N10-Formyltetrahydrofolate Synthetase Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, Formate--tetrahydrofolate ligase, SULFATE ION Authors: Celeste, L.R, Lovelace, L.L, Lebioda, L. Deposit date: 2013-03-06 Release date: 2013-03-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors. Protein Sci., 21, 2012
4JJ6	Crystal structure of a catalytic mutant of Axe2 (Axe2-H194A), an acetylxylan esterase from Geobacillus stearothermophilus Descriptor: Acetyl xylan esterase, CHLORIDE ION, GLYCEROL Authors: Lansky, S, Alalouf, O, Solomon, V, Alhassid, A, Belrahli, H, Govada, L, Chayan, N.E, Shoham, Y, Shoham, G. Deposit date: 2013-03-07 Release date: 2014-03-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: To be published To be published
2PMC	Crystal Structure of CheY-Mg(2+) in Complex with CheZ(C15) Peptide solved from a P1 Crystal Descriptor: Chemotaxis protein cheY, Chemotaxis protein cheZ, MAGNESIUM ION Authors: Guhaniyogi, J, Stock, A.M. Deposit date: 2007-04-20 Release date: 2008-01-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.688 Å) Cite: Interaction of CheY with the C-terminal peptide of CheZ. J.Bacteriol., 190, 2008
2ESK	Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type Descriptor: Ubiquitin-conjugating enzyme E2 D2 Authors: Ozkan, E, Yu, H, Deisenhofer, J. Deposit date: 2005-10-26 Release date: 2005-12-06 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases Proc.Natl.Acad.Sci.Usa, 102, 2005
3EBU	Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase Authors: Huang, X, Gibson, L.M, Bell, B.J, Lovelace, L.L, Pena, M.M, Berger, F.G, Berger, S.H. Deposit date: 2008-08-28 Release date: 2010-03-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry, 49, 2010

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