PDB: 8880 resultsInfo pagesStatus searchChemie searchBIRD

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6KLD	Structure of apo Machupo virus polymerase Descriptor: MANGANESE (II) ION, RNA-directed RNA polymerase L, ZINC ION Authors: Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. Deposit date: 2019-07-30 Release date: 2020-03-18 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural insight into arenavirus replication machinery. Nature, 579, 2020
6XZG	Influenza C virus polymerase in complex with chicken ANP32A - Subclass 3 Descriptor: Influenza viral RNA (vRNA) promoter 47mer, LRRcap domain-containing protein, Polymerase acidic protein, ... Authors: Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. Deposit date: 2020-02-04 Release date: 2020-11-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Host ANP32A mediates the assembly of the influenza virus replicase. Nature, 587, 2020
6XZR	Influenza C virus polymerase in complex with chicken ANP32A - Subclass 1 Descriptor: LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. Deposit date: 2020-02-05 Release date: 2020-11-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Host ANP32A mediates the assembly of the influenza virus replicase. Nature, 587, 2020
6XZP	Influenza C virus polymerase in complex with chicken ANP32A - Subclass 4 Descriptor: LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E. Deposit date: 2020-02-05 Release date: 2020-11-25 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Host ANP32A mediates the assembly of the influenza virus replicase. Nature, 587, 2020
7BEG	Structures of class I bacterial transcription complexes Descriptor: Class I pacrA promoter non-template DNA, Class I pacrA promoter template DNA, DNA-directed RNA polymerase subunit alpha, ... Authors: Ye, F.Z, Hao, M, Zhang, X.D. Deposit date: 2020-12-23 Release date: 2021-12-01 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation. Adv Sci, 9, 2022
5ZX2	Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor sigma H and 7nt RNA Descriptor: DNA (47-MER), DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2018-05-17 Release date: 2019-03-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for transcription initiation by bacterial ECF sigma factors. Nat Commun, 10, 2019
5N8X	Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus Descriptor: 3D polymerase, GLYCEROL, MANGANESE (II) ION Authors: Ferrer-Orta, C, Verdaguer, N. Deposit date: 2017-02-24 Release date: 2017-05-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
5D4D	Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP Descriptor: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (3 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.28 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP Descriptor: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2015-08-07 Release date: 2016-07-06 Last modified: 2024-07-03 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
6CCE	Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Kanglemycin A Descriptor: 1,2-ETHANEDIOL, DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2018-02-07 Release date: 2018-08-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
5M9Z	Second zinc-binding domain from yeast Pcf11 Descriptor: Protein PCF11, ZINC ION Authors: Mackereth, C. Deposit date: 2016-11-02 Release date: 2017-08-02 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing. Nucleic Acids Res., 45, 2017
6JCY	Mycobacterium tuberculosis RNA polymerase transcription initiation open complex with a chimeric ECF sigma factor sigH/E Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2019-01-30 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures and mechanism of transcription initiation by bacterial ECF factors. Nucleic Acids Res., 47, 2019
1Q79	CRYSTAL STRUCTURE OF MAMMALIAN POLY(A) POLYMERASE Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... Authors: Martin, G, Moglich, A, Keller, W, Doublie, S. Deposit date: 2003-08-16 Release date: 2004-09-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase. J.Mol.Biol., 341, 2004
1N35	lambda3 elongation complex with four phosphodiester bond formed Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*CP*CP*CP*CP*C)-3', 5'-R(P*GP*GP*GP*GP*G)-3', ... Authors: Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. Deposit date: 2002-10-25 Release date: 2002-12-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3 Cell(Cambridge,Mass.), 111, 2002
6XH8	CueR-transcription activation complex with RNA transcript Descriptor: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W, Yang, Y. Deposit date: 2020-06-18 Release date: 2021-04-14 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
6XH7	CueR-TAC without RNA Descriptor: COPPER (II) ION, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Shi, W, Yang, Y. Deposit date: 2020-06-18 Release date: 2021-04-14 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of copper-efflux-regulator-dependent transcription activation. Iscience, 24, 2021
5N9J	Core Mediator of transcriptional regulation Descriptor: Mediator Complex Subunit 9, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... Authors: Nozawa, K, Schneider, T.R, Cramer, P. Deposit date: 2017-02-25 Release date: 2017-05-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Core Mediator structure at 3.4 Angstrom extends model of transcription initiation complex. Nature, 545, 2017
3MF5	Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor Descriptor: 3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid, GLYCEROL, RNA-directed RNA polymerase Authors: Harris, S.F, Tavares, G, Ghate, M. Deposit date: 2010-04-01 Release date: 2010-07-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
8PNT	Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... Authors: Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J. Deposit date: 2023-07-01 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43, 2024
8GWE	SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP Descriptor: Helicase nsp13, MAGNESIUM ION, Non-structural protein 8, ... Authors: Yan, L.M, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-16 Release date: 2023-01-11 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
3K5M	Crystal structure of E.coli Pol II-abasic DNA-ddGTP Lt(-2, 2) ternary complex Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*TP*CP*CP*TP*GP*(3DR)P*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), ... Authors: Yang, W, Wang, F. Deposit date: 2009-10-07 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structural insight into translesion synthesis by DNA Pol II. Cell(Cambridge,Mass.), 139, 2009
8GWF	A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... Authors: Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. Deposit date: 2022-09-17 Release date: 2023-01-11 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
6FHI	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker. Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Lukarska, M, Cusack, S. Deposit date: 2018-01-14 Release date: 2019-01-30 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published
4ZQQ	Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region Descriptor: MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, SULFATE ION Authors: Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Neya, S, Hoshino, T. Deposit date: 2015-05-11 Release date: 2015-06-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit. Biochemistry, 55, 2016

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