8HIM
| A cryo-EM structure of B. oleracea RNA polymerase V elongation complex at 2.73 Angstrom | Descriptor: | DNA (34-MER), DNA-directed RNA polymerase IV and V subunit 2, DNA-directed RNA polymerase V largest subunit, ... | Authors: | Hu, H, Xie, G, Du, X, Du, J. | Deposit date: | 2022-11-21 | Release date: | 2023-03-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure and mechanism of the plant RNA polymerase V. Science, 379, 2023
|
|
2RUD
| |
4URW
| The crystal structure of H-Ras and SOS in complex with ligands | Descriptor: | 2-(2,6-DIMETHYLPHENYL)-4-(METHYLSULFANYL)-6-(PIPERAZIN-1-YL)-1,3,5-TRIAZINE, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1 | Authors: | Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. | Deposit date: | 2014-07-02 | Release date: | 2015-03-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
|
|
5SPV
| PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with REAL250003774401 | Descriptor: | 2-[methyl-[(9-oxidanylidene-1$l^{4},7,8-triazabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl)carbonyl]amino]ethanoic acid, Non-structural protein 3 | Authors: | Correy, G.J, Fraser, J.S. | Deposit date: | 2022-06-09 | Release date: | 2022-07-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
2RRK
| |
8HB3
| Crystal structure of NAD-II riboswitch (two strands) with NR | Descriptor: | Nicotinamide riboside, RNA (31-MER), RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') | Authors: | Peng, X, Lilley, D.M.J, Huang, L. | Deposit date: | 2022-10-27 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets. Nucleic Acids Res., 51, 2023
|
|
8HGW
| Crystal structure of MehpH in complex with MBP | Descriptor: | 1-BUTANOL, Monoalkyl phthalate hydrolase, PHTHALIC ACID | Authors: | Zhang, Z.M, Wang, Y.J, Chen, Y.B. | Deposit date: | 2022-11-15 | Release date: | 2023-03-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.80001163 Å) | Cite: | Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase. Commun Chem, 6, 2023
|
|
4US6
| New Crystal Form of Glucose Isomerase Grown in Short Peptide Supramolecular Hydrogels | Descriptor: | CALCIUM ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Gavira, J.A, Conejero-Muriel, M, Diaz-Mochon, J.J, Alvarez de Cienfuegos, L. | Deposit date: | 2014-07-03 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Influence of the Chirality of Short Peptide Supramolecular Hydrogels in Protein Crystallogenesis. Chem.Commun.(Camb.), 51, 2015
|
|
5SPQ
| |
4V3O
| Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | Descriptor: | ACETATE ION, CALCIUM ION, YIII_M5_AII | Authors: | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | Deposit date: | 2014-10-20 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects Acta Crystallogr.,Sect.D, 72, 2016
|
|
8HGV
| |
5SPW
| PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with FRESH00004674769 - (R,S,R) isomer | Descriptor: | (1R,5S,6R)-3-(7H-purin-6-yl)-3-azabicyclo[3.2.2]nonane-6-carboxylic acid, Non-structural protein 3 | Authors: | Correy, G.J, Fraser, J.S. | Deposit date: | 2022-06-09 | Release date: | 2022-07-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4US8
| Aldehyde Oxidoreductase from Desulfovibrio gigas (MOP), soaked with benzaldehyde | Descriptor: | (MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V), ALDEHYDE OXIDOREDUCTASE, BICARBONATE ION, ... | Authors: | Correia, H.D, Romao, M.J, Santos-Silva, T. | Deposit date: | 2014-07-03 | Release date: | 2014-10-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Aromatic Aldehydes at the Active Site of Aldehyde Oxidoreductase from Desulfovibrio Gigas: Reactivity and Molecular Details of the Enzyme-Substrate and Enzyme-Product Interaction. J.Biol.Inorg.Chem., 20, 2015
|
|
8HHT
| Crystal structure of the SARS-CoV-2 main protease in complex with Hit-1 | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(1,3-thiazol-2-ylmethylamino)butan-2-yl]benzamide | Authors: | Zeng, R, Xie, L.W, Huang, C, Wang, K, Liu, Y.Z, Yang, S.Y, Lei, J. | Deposit date: | 2022-11-17 | Release date: | 2023-03-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal Transduct Target Ther, 8, 2023
|
|
2RU0
| |
4UTL
| XenA - reduced - Y183F variant in complex with coumarin | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, COUMARIN, SULFATE ION, ... | Authors: | Werther, T, Dobbek, H. | Deposit date: | 2014-07-21 | Release date: | 2015-08-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.229 Å) | Cite: | Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase Nat Commun, 8, 2017
|
|
8HJ0
| GPR21(m5) and G15 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Chen, B, Lin, X. | Deposit date: | 2022-11-22 | Release date: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
|
|
2RQ2
| The solution structure of the N-terminal fragment of big defensin | Descriptor: | Big defensin | Authors: | Kouno, T, Mizuguchi, M, Aizawa, T, Shinoda, H, Demura, M, Kawabata, S, Kawano, K. | Deposit date: | 2009-01-07 | Release date: | 2009-08-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A novel beta-defensin structure: big defensin changes its N-terminal structure to associate with the target membrane Biochemistry, 48, 2009
|
|
8GYW
| Cryo-EM structure of human CEPT1 complexed with CDP-choline | Descriptor: | Choline/ethanolaminephosphotransferase 1, MAGNESIUM ION, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM | Authors: | Qian, H.W, Wang, Z.H. | Deposit date: | 2022-09-24 | Release date: | 2023-03-22 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1. Nat Commun, 14, 2023
|
|
4UY6
| |
4V3R
| Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | Descriptor: | MAGNESIUM ION, YIII_M5_AII | Authors: | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | Deposit date: | 2014-10-20 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects Acta Crystallogr.,Sect.D, 72, 2016
|
|
2RUT
| Solution structures of the DNA-binding domain (ZF2) of immune-related zinc-finger protein ZFAT | Descriptor: | ZINC ION, Zinc finger protein ZFAT | Authors: | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | Deposit date: | 2015-01-26 | Release date: | 2015-04-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT. J Struct Funct Genomics, 16, 2015
|
|
8HCQ
| Cryo-EM structure of endothelin1-bound ETAR-Gq complex | Descriptor: | Endothelin-1, Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | Deposit date: | 2022-11-02 | Release date: | 2023-03-22 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
|
|
2RKV
| Crystal Structure of F. graminearum TRI101 complexed with Coenzyme A and T-2 mycotoxin | Descriptor: | 12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, COENZYME A, ... | Authors: | Garvey, G.S, Rayment, I. | Deposit date: | 2007-10-17 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and Functional Characterization of the TRI101 Trichothecene 3-O-Acetyltransferase from Fusarium sporotrichioides and Fusarium graminearum: KINETIC INSIGHTS TO COMBATING FUSARIUM HEAD BLIGHT J.Biol.Chem., 283, 2008
|
|
8GY1
| |