PDB: 1870 resultsInfo pagesStatus searchChemie searchBIRD

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3RB9	Crystal structure of the M. tuberculosis beta clamp Descriptor: DNA polymerase III subunit beta Authors: Kukshal, V, Ramachandran, R. Deposit date: 2011-03-29 Release date: 2012-04-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: M. tuberculosis Sliding beta-Clamp Does Not Interact Directly with the NAD(+)-Dependent DNA Ligase Plos One, 7, 2012
1R08	STRUCTURAL ANALYSIS OF ANTIVIRAL AGENTS THAT INTERACT WITH THE CAPSID OF HUMAN RHINOVIRUSES Descriptor: 5-(5-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-(HYDROXYETHYL OXYMETHYLENEOXYMETHYL) ISOXAZOLE, HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 14 COAT PROTEIN (SUBUNIT VP2), ... Authors: Badger, J, Smith, T.J, Rossmann, M.G. Deposit date: 1988-10-03 Release date: 1990-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses. Proteins, 6, 1989
5NAS	Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide Descriptor: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta Authors: Boura, E, Eisenreichova, A. Deposit date: 2017-02-28 Release date: 2017-03-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide To Be Published
8C6J	Human spliceosomal PM5 C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Dybkov, O, Kastner, B, Luehrmann, R. Deposit date: 2023-01-12 Release date: 2023-07-12 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Sci Adv, 9, 2023
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
7W59	The cryo-EM structure of human pre-C*-I complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5B	The cryo-EM structure of human C* complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
7W5A	The cryo-EM structure of human pre-C*-II complex Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhan, X, Lu, Y, Shi, Y. Deposit date: 2021-11-29 Release date: 2022-06-22 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
6FD7	NMR structure of the first TPR domain of the human RPAP3 protein Descriptor: RNA polymerase II-associated protein 3 Authors: Quinternet, M, Chagot, M.E, Manival, X. Deposit date: 2017-12-22 Release date: 2018-08-01 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A Descriptor: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-12-30 Release date: 2023-12-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8B5P	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 10 Descriptor: 14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-09-23 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B4Q	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5 Descriptor: 14-3-3 protein sigma, 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-09-20 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B2I	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 4 Descriptor: 14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-09-14 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B2K	Ternary structure of 14-3-3s, RND3 phosphopeptide and dual-reactive compound 10 Descriptor: 14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-09-14 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BJG	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8 Descriptor: 14-3-3 protein sigma, 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-11-04 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BJN	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6 Descriptor: 14-3-3 protein sigma, 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-11-04 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BM5	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7 Descriptor: 14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide, CHLORIDE ION, ... Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-11-10 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8FOW	Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... Authors: Schonbrunn, E, Sun, L. Deposit date: 2023-01-03 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
8FP0	Ternary complex of CDK2 with small molecule ligands TW8672 and Roscovitine Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2, ... Authors: Schonbrunn, E, Sun, L. Deposit date: 2023-01-03 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
1QJX	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND WIN68934 Descriptor: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[4-METHYL-2H-TETRAZOL-2-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... Authors: Hadfield, A.T, Diana, G.D, Rossmann, M.G. Deposit date: 1999-07-06 Release date: 1999-07-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
3JAH	Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... Authors: Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. Deposit date: 2015-06-10 Release date: 2015-08-12 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
3JAG	Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... Authors: Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. Deposit date: 2015-06-10 Release date: 2015-08-12 Last modified: 2018-07-18 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Structural basis for stop codon recognition in eukaryotes. Nature, 524, 2015
1HD7	A Second Divalent Metal Ion in the Active Site of a New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and its Implications for the Catalytic Mechanism Descriptor: DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION Authors: Beernink, P.T, Segelke, B.W, Rupp, B. Deposit date: 2000-11-09 Release date: 2001-02-16 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307, 2001
5YZG	The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. Deposit date: 2017-12-14 Release date: 2018-08-08 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of a human catalytic step I spliceosome Science, 359, 2018

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