1HD7

A Second Divalent Metal Ion in the Active Site of a New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and its Implications for the Catalytic Mechanism

Summary for 1HD7

Entry DOI	10.2210/pdb1hd7/pdb
Related	1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N
Descriptor	DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION (3 entities in total)
Functional Keywords	dna repair, endonuclease, ape1, hap1, ref-1
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695
Total number of polymer chains	1
Total formula weight	35813.69
Authors	Beernink, P.T.,Segelke, B.W.,Rupp, B. (deposition date: 2000-11-09, release date: 2001-02-16, Last modification date: 2011-07-13)
Primary citation	Beernink, P.T.,Segelke, B.W.,Hadi, M.Z.,Erzberger, J.P.,Wilson III, D.M.,Rupp, B. Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307:1023-, 2001 Cited by PubMed: 11286553 DOI: 10.1006/JMBI.2001.4529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation