1DE9

HUMAN APE1 ENDONUCLEASE WITH BOUND ABASIC DNA AND MN2+ ION

Summary for 1DE9

• Entry DOI: 10.2210/pdb1de9/pdb
• Related: 1BIX 1DE8
• Descriptor: 5'-d(*CP*TP*AP*C)-3', 5'-d(P*(3DR)P*GP*AP*TP*C)-3', 5'-d(*GP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... (5 entities in total)
• Functional Keywords: enzyme:dna complex, dna repair abasic site, ap endonuclease, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695
• Total number of polymer chains: 8
• Total formula weight: 73142.15

Authors

Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A. (deposition date: 1999-11-13, release date: 2000-02-02, Last modification date: 2024-02-07)

• Primary citation: Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A.; DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination; Nature, 403:451-456, 2000; PubMed: 10667800; DOI: 10.1038/35000249

Experimental method

X-RAY DIFFRACTION (3 Å)