1DE8
HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1) BOUND TO ABASIC DNA
Summary for 1DE8
Entry DOI | 10.2210/pdb1de8/pdb |
Related | 1BIX |
Descriptor | DNA (5'-D(*GP*CP*TP*AP*CP*(3DR)P*GP*AP*TP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE, ... (4 entities in total) |
Functional Keywords | enzyme:dna complex, dna repair, abasic site, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695 |
Total number of polymer chains | 6 |
Total formula weight | 75595.74 |
Authors | Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A. (deposition date: 1999-11-13, release date: 2000-02-02, Last modification date: 2024-02-07) |
Primary citation | Mol, C.D.,Izumi, T.,Mitra, S.,Tainer, J.A. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected Nature, 403:451-456, 2000 Cited by PubMed: 10667800DOI: 10.1038/35000249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
Download full validation report