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1FHS	THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES Descriptor: GROWTH FACTOR RECEPTOR BOUND PROTEIN-2 Authors: Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S. Deposit date: 1997-06-12 Release date: 1998-06-17 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2. J.Biomol.NMR, 11, 1998
1FU6	NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT Authors: Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. Deposit date: 2000-09-14 Release date: 2001-02-21 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
1FU5	NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN Descriptor: DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT Authors: Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. Deposit date: 2000-09-14 Release date: 2001-02-21 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
1FYR	DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE Authors: Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C. Deposit date: 2000-10-03 Release date: 2000-12-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex. Biochemistry, 39, 2000
1GHU	NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures Descriptor: GRB2 Authors: Thornton, K.H, Mueller, W.T, Mcconnell, P, Zhu, G, Saltiel, A.R, Thanabal, V. Deposit date: 1996-08-05 Release date: 1997-01-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry, 35, 1996
1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION Authors: Rahuel, J. Deposit date: 1998-03-26 Release date: 1999-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide Descriptor: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 Authors: Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. Deposit date: 2010-03-24 Release date: 2010-05-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-07 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
1HCT	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. Descriptor: AICD peptide E683V variant, Growth factor receptor-bound protein 2 Authors: Sen, U, Das, S. Deposit date: 2010-05-08 Release date: 2011-05-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
1HCS	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX Descriptor: ACETYL-PYEEIE-OH, HUMAN SRC Authors: Gampe Junior, R.T, Xu, R.X. Deposit date: 1994-09-02 Release date: 1995-09-15 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1H9O	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. Deposit date: 2001-03-14 Release date: 2001-03-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.79 Å) Cite: NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP Descriptor: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-28 Release date: 2010-12-15 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 Descriptor: Tyrosine-protein phosphatase, non-receptor type 6 Authors: Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-05-17 Release date: 2005-11-17 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV Descriptor: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 Authors: Whiddon, B.B, Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP Descriptor: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-05-27 Release date: 2011-01-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
7RNV	SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNS	nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.14 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7SA7	Crystal structure of the apo SH2 domains of Syk Descriptor: Tyrosine-protein kinase SYK Authors: Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. Deposit date: 2021-09-22 Release date: 2021-10-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021

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