7OZ0
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3KQ6
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![BU of 3kq6 by Molmil](/molmil-images/mine/3kq6) | Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | Deposit date: | 2009-11-17 | Release date: | 2010-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
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2GPJ
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6S8X
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![BU of 6s8x by Molmil](/molmil-images/mine/6s8x) | Crystal structure of the Rab-binding domain of FIP2 | Descriptor: | HEXANE-1,6-DIOL, Rab11 family-interacting protein 2 | Authors: | Kearney, A.M, Khan, A.R. | Deposit date: | 2019-07-10 | Release date: | 2020-08-05 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structure of the Rab-binding domain of Rab11 family-interacting protein 2. Acta Crystallogr.,Sect.F, 76, 2020
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7XLZ
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3EU9
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![BU of 3eu9 by Molmil](/molmil-images/mine/3eu9) | The ankyrin repeat domain of Huntingtin interacting protein 14 | Descriptor: | GLYCEROL, HISTIDINE, Huntingtin-interacting protein 14, ... | Authors: | Gao, T, Collins, R.E, Horton, J.R, Zhang, R, Zhang, X, Cheng, X. | Deposit date: | 2008-10-09 | Release date: | 2009-06-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins, 76, 2009
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2DLO
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2DIL
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![BU of 2dil by Molmil](/molmil-images/mine/2dil) | Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1 | Descriptor: | Proline-serine-threonine phosphatase-interacting protein 1 | Authors: | Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-03-30 | Release date: | 2007-02-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the SH3 domain of the human Proline-serine-threonine phosphatase-interacting protein 1 To be Published
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4LL1
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![BU of 4ll1 by Molmil](/molmil-images/mine/4ll1) | The structure of the TRX and TXNIP complex | Descriptor: | Thioredoxin, Thioredoxin-interacting protein | Authors: | Hwang, J, Kim, M.H. | Deposit date: | 2013-07-09 | Release date: | 2014-02-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein Nat Commun, 5, 2014
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3B70
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![BU of 3b70 by Molmil](/molmil-images/mine/3b70) | Crystal structure of Aspergillus terreus trans-acting lovastatin polyketide enoyl reductase (LovC) with bound NADP | Descriptor: | Enoyl reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Ames, B.D, Smith, P.T, Ma, S.M, Wong, E.W, Xie, X, Vederas, J.C, Tang, Y, Tsai, S.-C. | Deposit date: | 2007-10-29 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc.Natl.Acad.Sci.USA, 109, 2012
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4LL4
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![BU of 4ll4 by Molmil](/molmil-images/mine/4ll4) | The structure of the TRX and TXNIP complex | Descriptor: | Thioredoxin, Thioredoxin-interacting protein | Authors: | Hwang, J, Kim, M.H. | Deposit date: | 2013-07-09 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein Nat Commun, 5, 2014
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3E46
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![BU of 3e46 by Molmil](/molmil-images/mine/3e46) | Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A mutant | Descriptor: | CALCIUM ION, Ubiquitin-conjugating enzyme E2-25 kDa | Authors: | Hughes, R.C, Wilson, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D. | Deposit date: | 2008-08-09 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). Acta Crystallogr.,Sect.F, 65, 2009
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6T2R
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![BU of 6t2r by Molmil](/molmil-images/mine/6t2r) | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown | Descriptor: | Beta-glycosidase, SULFATE ION | Authors: | Crouch, L.I, Liberato, M.V, Ubranowicz, P.A, Basle, A, Lamb, C.A, Cooke, K, Doona, M, Needham, S, Brady, R.R, Berrington, J.E, Madubic, K, Chater, P, Zhang, F, Linhardt, R.J, Spence, D.I.R, Bolam, D.N. | Deposit date: | 2019-10-09 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun, 11, 2020
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1O06
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![BU of 1o06 by Molmil](/molmil-images/mine/1o06) | Crystal structure of the Vps27p Ubiquitin Interacting Motif (UIM) | Descriptor: | Vacuolar protein sorting-associated protein VPS27, ZINC ION | Authors: | Fisher, R.D, Wang, B, Alam, S.L, Higginson, D.S, Rich, R, Myszka, D, Sundquist, W.I, Hill, C.P. | Deposit date: | 2003-02-20 | Release date: | 2003-07-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure and ubiquitin binding of the ubiquitin-interacting motif. J.Biol.Chem., 278, 2003
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2D7C
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![BU of 2d7c by Molmil](/molmil-images/mine/2d7c) | Crystal structure of human Rab11 in complex with FIP3 Rab-binding domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Shiba, T, Koga, H, Shin, H.W, Kawasaki, M, Kato, R, Nakayama, K, Wakatsuki, S. | Deposit date: | 2005-11-16 | Release date: | 2006-09-26 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. Proc.Natl.Acad.Sci.Usa, 103, 2006
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7EFX
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![BU of 7efx by Molmil](/molmil-images/mine/7efx) | Crystal Structure of human PIN1 complexed with covalent inhibitor | Descriptor: | 4-((5-bromofuran-2-yl)methyl)-8-(2-chloroacetyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Liu, L, Li, J, Zhu, R, Pei, Y. | Deposit date: | 2021-03-23 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7EKV
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![BU of 7ekv by Molmil](/molmil-images/mine/7ekv) | Crystal Structure of human Pin1 complexed with a covalent inhibitor | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-((5-phenylfuran-2-yl)methyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Liu, L, Li, J. | Deposit date: | 2021-04-06 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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7EFJ
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![BU of 7efj by Molmil](/molmil-images/mine/7efj) | Crystal Structure Analysis of human PIN1 | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 8-(2-chloroacetyl)-4-(furan-2-ylmethyl)-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Liu, L, Li, J. | Deposit date: | 2021-03-21 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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6T2P
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![BU of 6t2p by Molmil](/molmil-images/mine/6t2p) | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Glycosyl hydrolase family 16 | Authors: | Crouch, L.I, Liberato, M.V, Ubranowicz, P.A, Basle, A, Lamb, C.A, Cooke, K, Doona, M, Needham, S, Brady, R.R, Berrington, J.E, Madubic, K, Chater, P, Zhang, F, Linhardt, R.J, Spence, D.I.R, Bolam, D.N. | Deposit date: | 2019-10-09 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun, 11, 2020
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7BG0
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![BU of 7bg0 by Molmil](/molmil-images/mine/7bg0) | Fusion of MBP and the backbone of the long-acting amylin analog AM833. | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Islet amyloid polypeptide, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Johansson, E. | Deposit date: | 2021-01-05 | Release date: | 2021-08-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Development of Cagrilintide, a Long-Acting Amylin Analogue. J.Med.Chem., 64, 2021
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6T2O
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![BU of 6t2o by Molmil](/molmil-images/mine/6t2o) | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Glycosyl hydrolase family 16 | Authors: | Crouch, L.I, Liberato, M.V, Ubranowicz, P.A, Basle, A, Lamb, C.A, Cooke, K, Doona, M, Needham, S, Brady, R.R, Berrington, J.E, Madubic, K, Chater, P, Zhang, F, Linhardt, R.J, Spence, D.I.R, Bolam, D.N. | Deposit date: | 2019-10-09 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun, 11, 2020
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6T2S
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![BU of 6t2s by Molmil](/molmil-images/mine/6t2s) | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown | Descriptor: | Glycoside hydrolase family 16 protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | Authors: | Crouch, L.I, Liberato, M.V, Ubranowicz, P.A, Basle, A, Lamb, C.A, Cooke, K, Doona, M, Needham, S, Brady, R.R, Berrington, J.E, Madubic, K, Chater, P, Zhang, F, Linhardt, R.J, Spence, D.I.R, Bolam, D.N. | Deposit date: | 2019-10-09 | Release date: | 2020-07-08 | Last modified: | 2020-08-26 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun, 11, 2020
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6T2Q
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![BU of 6t2q by Molmil](/molmil-images/mine/6t2q) | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Glycosyl hydrolase family 16, ... | Authors: | Crouch, L.I, Liberato, M.V, Ubranowicz, P.A, Basle, A, Lamb, C.A, Cooke, K, Doona, M, Needham, S, Brady, R.R, Berrington, J.E, Madubic, K, Chater, P, Zhang, F, Linhardt, R.J, Spence, D.I.R, Bolam, D.N. | Deposit date: | 2019-10-09 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun, 11, 2020
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7F0M
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![BU of 7f0m by Molmil](/molmil-images/mine/7f0m) | Crystal Structure of human Pin1 complexed with a potent covalent inhibitor | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 8-(2-chloranylethanoyl)-4-[(5-naphthalen-1-ylfuran-2-yl)methyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Liu, L, Li, J. | Deposit date: | 2021-06-05 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J.Med.Chem., 65, 2022
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2ESW
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![BU of 2esw by Molmil](/molmil-images/mine/2esw) | |