5WW6
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![BU of 5ww6 by Molmil](/molmil-images/mine/5ww6) | |
7D4V
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![BU of 7d4v by Molmil](/molmil-images/mine/7d4v) | Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase Y91F/C120S variant | Descriptor: | Methylated-DNA--protein-cysteine methyltransferase, SULFATE ION | Authors: | Kikuchi, M, Yamauchi, T, Iizuka, Y, Tsunoda, M. | Deposit date: | 2020-09-24 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Roles of the hydroxy group of tyrosine in crystal structures of Sulfurisphaera tokodaii O6-methylguanine-DNA methyltransferase. Acta Crystallogr.,Sect.F, 77, 2021
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6OR7
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![BU of 6or7 by Molmil](/molmil-images/mine/6or7) | Structure of HIV-1 Reverse Transcriptase (RT) in complex with DNA AND (-)FTC-TP | Descriptor: | DNA Primer 20-mer, DNA template 27-mer, MAGNESIUM ION, ... | Authors: | Bertoletti, N, Chan, A.H, Anderson, K.S. | Deposit date: | 2019-04-29 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28, 2019
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1CDW
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![BU of 1cdw by Molmil](/molmil-images/mine/1cdw) | HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA | Descriptor: | DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)) | Authors: | Nikolov, D.B, Chen, H, Halay, E.D, Hoffmann, A, Roeder, R.G, Burley, S.K. | Deposit date: | 1996-04-11 | Release date: | 1996-12-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a human TATA box-binding protein/TATA element complex. Proc.Natl.Acad.Sci.USA, 93, 1996
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7OOO
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![BU of 7ooo by Molmil](/molmil-images/mine/7ooo) | The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG containing an LNA-Amide-LNA modification | Descriptor: | DNA (5'-D(*CP*TP*(05A)P*TP*CP*TP*TP*TP*G)-3'), MAGNESIUM ION, RNA (5'-R(*CP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3') | Authors: | Thorpe, C, Hardwick, J, McDonough, M.A, Hall, J.P, Baker, Y.R, El-Sagheer, A.H, Brown, T. | Deposit date: | 2021-05-28 | Release date: | 2022-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nat Commun, 13, 2022
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8U0J
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![BU of 8u0j by Molmil](/molmil-images/mine/8u0j) | DdmE in complex with guide and target DNA | Descriptor: | DNA (5'-D(P*AP*CP*TP*TP*AP*AP*AP*GP*TP*CP*TP*AP*AP*CP*CP*TP*AP*TP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*AP*TP*AP*GP*GP*A)-3'), DNA (5'-D(P*GP*TP*TP*AP*GP*AP*CP*TP*TP*TP*AP*AP*GP*T)-3'), ... | Authors: | Bravo, J.P.K. | Deposit date: | 2023-08-29 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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8U0W
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![BU of 8u0w by Molmil](/molmil-images/mine/8u0w) | DdmD monomer in complex with ssDNA | Descriptor: | DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein | Authors: | Bravo, J.P.K. | Deposit date: | 2023-08-29 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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5DDG
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![BU of 5ddg by Molmil](/molmil-images/mine/5ddg) | The structure of transcriptional factor AraR from Bacteroides thetaiotaomicron VPI in complex with target double strand DNA | Descriptor: | DNA (27-MER), FORMIC ACID, MALONIC ACID, ... | Authors: | Chang, C, Tesar, C, Rodionov, D, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-08-24 | Release date: | 2015-09-09 | Last modified: | 2015-12-16 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A novel transcriptional regulator of L-arabinose utilization in human gut bacteria. Nucleic Acids Res., 43, 2015
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1EVW
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![BU of 1evw by Molmil](/molmil-images/mine/1evw) | L116A MUTANT OF THE HOMING ENDONUCLEASE I-PPOI COMPLEXED TO HOMING SITE DNA. | Descriptor: | DNA (5'-D(*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*TP*AP*CP*CP*TP*TP*AP*A)-3'), DNA (5'-D(P*GP*AP*GP*AP*GP*TP*CP*A)-3'), ... | Authors: | Galburt, E.A, Jurica, M.S, Chevalier, B.S, Erho, D, Stoddard, B.L. | Deposit date: | 2000-04-20 | Release date: | 2000-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site. J.Mol.Biol., 300, 2000
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1WET
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![BU of 1wet by Molmil](/molmil-images/mine/1wet) | STRUCTURE OF THE PURR-GUANINE-PURF OPERATOR COMPLEX | Descriptor: | DNA (5'-D(*AP*AP*CP*GP*AP*AP*AP*AP*CP*GP*TP*TP*TP*TP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | Authors: | Schumacher, M.A, Glasfeld, A, Zalkin, H, Brennan, R.G. | Deposit date: | 1997-04-27 | Release date: | 1997-11-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinity. J.Biol.Chem., 272, 1997
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2M8Y
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![BU of 2m8y by Molmil](/molmil-images/mine/2m8y) | Structure of d[CGCGAAGCATTCGCG] hairpin | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*GP*CP*AP*TP*TP*CP*GP*CP*G)-3') | Authors: | Lim, K.W, Phan, A.T. | Deposit date: | 2013-05-30 | Release date: | 2013-07-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis of DNA quadruplex-duplex junction formation. Angew.Chem.Int.Ed.Engl., 52, 2013
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4PCB
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![BU of 4pcb by Molmil](/molmil-images/mine/4pcb) | Conjugative Relaxase TrwC in complex with mutant OriT Dna | Descriptor: | DNA 5'-D(P*GP*CP*AP*CP*CP*GP*AP*AP*GP*GP*TP*GP*CP*GP*TP*AP*TP*TP*CP*TP*TP*GP - 3'), PHOSPHATE ION, TrwC | Authors: | Moncalian, G, Carballeira, J.D, de la Cruz, F, Gonzalez-Perez, B. | Deposit date: | 2014-04-14 | Release date: | 2014-09-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A high security double lock and key mechanism in HUH relaxases controls oriT-processing for plasmid conjugation. Nucleic Acids Res., 42, 2014
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7OOS
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![BU of 7oos by Molmil](/molmil-images/mine/7oos) | The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG | Descriptor: | DNA (5'-D(*CP*TP*(05K)P*TP*CP*TP*TP*TP*G)-3'), RNA (5'-R(*CP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3'), STRONTIUM ION | Authors: | Thorpe, C, Hardwick, J, McDonough, M.A, Hall, J.P, Baker, Y.R, El-Sagheer, A.H, Brown, T. | Deposit date: | 2021-05-28 | Release date: | 2022-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nat Commun, 13, 2022
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7OZZ
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![BU of 7ozz by Molmil](/molmil-images/mine/7ozz) | The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG with LNA-amide modification | Descriptor: | DNA (5'-D(*CP*TP*(05H)P*TP*CP*TP*TP*TP*G)-3'), POTASSIUM ION, RNA (5'-R(*CP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3') | Authors: | Thorpe, C, Hardwick, J, McDonough, M.A, Hall, J.P, Baker, Y.R, El-Sagheer, A.H, Brown, T. | Deposit date: | 2021-06-29 | Release date: | 2022-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nat Commun, 13, 2022
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8U72
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![BU of 8u72 by Molmil](/molmil-images/mine/8u72) | Cryo-EM structure of the SPARTA oligomer with guide RNA and target DNA | Descriptor: | DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*C)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... | Authors: | Malik, R, Kottur, J, Aggarwal, A.K. | Deposit date: | 2023-09-14 | Release date: | 2024-06-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Nucleic acid mediated activation of a short prokaryotic Argonaute immune system. Nat Commun, 15, 2024
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5ZOF
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![BU of 5zof by Molmil](/molmil-images/mine/5zof) | Crystal Structure of D181A/R192F hFen1 in complex with DNA | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ... | Authors: | Han, W, Hua, Y, Zhao, Y. | Deposit date: | 2018-04-13 | Release date: | 2019-01-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.249 Å) | Cite: | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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1LCC
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![BU of 1lcc by Molmil](/molmil-images/mine/1lcc) | STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | Descriptor: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | Authors: | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | Deposit date: | 1993-03-25 | Release date: | 1994-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J.Mol.Biol., 234, 1993
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4J3N
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![BU of 4j3n by Molmil](/molmil-images/mine/4j3n) | Human Topoisomerase Iibeta in complex with DNA | Descriptor: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | Authors: | Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. | Deposit date: | 2013-02-06 | Release date: | 2013-10-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
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7D3T
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![BU of 7d3t by Molmil](/molmil-images/mine/7d3t) | Crystal structure of OSPHR2 in complex with DNA | Descriptor: | DNA (5'-D(P*CP*TP*CP*GP*GP*AP*TP*AP*TP*CP*CP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*GP*CP*TP*TP*GP*AP*GP*GP*AP*TP*AP*TP*CP*CP*GP*A)-3'), Protein PHOSPHATE STARVATION RESPONSE 2 | Authors: | Guan, Z.Y, Zhang, Z.F, Liu, Z. | Deposit date: | 2020-09-20 | Release date: | 2021-10-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex. Nat Commun, 13, 2022
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5ZOE
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![BU of 5zoe by Molmil](/molmil-images/mine/5zoe) | Crystal Structure of D181A hFen1 in complex with DNA | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), DNA (5'-D(*GP*CP*CP*CP*GP*TP*CP*C)-3'), ... | Authors: | Han, W, Hua, Y, Zhao, Y. | Deposit date: | 2018-04-13 | Release date: | 2019-01-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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5ZOG
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![BU of 5zog by Molmil](/molmil-images/mine/5zog) | Crystal Structure of R192F hFen1 in complex with DNA | Descriptor: | DNA (5'-D(*CP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*G)-3'), ... | Authors: | Han, W, Hua, Y, Zhao, Y. | Deposit date: | 2018-04-13 | Release date: | 2019-01-30 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic Acids Res., 46, 2018
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1ZVV
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![BU of 1zvv by Molmil](/molmil-images/mine/1zvv) | Crystal structure of a ccpa-crh-dna complex | Descriptor: | DNA recognition strand CRE, Glucose-resistance amylase regulator, HPr-like protein crh, ... | Authors: | Schumacher, M.A, Brennan, R.G, Hillen, W, Seidel, G. | Deposit date: | 2005-06-02 | Release date: | 2006-02-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. J.Biol.Chem., 281, 2006
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6UJX
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![BU of 6ujx by Molmil](/molmil-images/mine/6ujx) | HIV-1 wild-type reverse transcriptase-DNA complex with (-)-FTC-TP | Descriptor: | DNA primer, DNA template, MAGNESIUM ION, ... | Authors: | Lansdon, E.B. | Deposit date: | 2019-10-03 | Release date: | 2019-12-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.70451212 Å) | Cite: | Elucidating molecular interactions ofL-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance. Commun Biol, 2, 2019
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7AII
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![BU of 7aii by Molmil](/molmil-images/mine/7aii) | HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR WITH BOUND MANGANESE | Descriptor: | DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ... | Authors: | Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. | Deposit date: | 2020-09-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021
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7AIJ
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![BU of 7aij by Molmil](/molmil-images/mine/7aij) | HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR | Descriptor: | DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(P*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), Gag-Pol polyprotein, ... | Authors: | Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. | Deposit date: | 2020-09-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021
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