4J3N
Human Topoisomerase Iibeta in complex with DNA
Summary for 4J3N
Entry DOI | 10.2210/pdb4j3n/pdb |
Related | 3QX3 4G0U 4G0V 4G0W |
Descriptor | DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (5 entities in total) |
Functional Keywords | toprim domain, winged-helix domain, coiled-coil domain, dna binding and cleavage, nucleus, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q02880 |
Total number of polymer chains | 6 |
Total formula weight | 196208.86 |
Authors | Wu, C.C.,Li, T.K.,Li, Y.C.,Chan, N.L. (deposition date: 2013-02-06, release date: 2013-10-02, Last modification date: 2023-11-08) |
Primary citation | Wu, C.C.,Li, Y.C.,Wang, Y.R.,Li, T.K.,Chan, N.L. On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41:10630-10640, 2013 Cited by PubMed: 24038465DOI: 10.1093/nar/gkt828 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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