3GOZ
| Crystal structure of the leucine-rich repeat-containing protein LegL7 from Legionella pneumophila. Northeast Structural Genomics Consortium target LgR148 | Descriptor: | Leucine-rich repeat-containing protein | Authors: | Vorobiev, S.M, Abashidze, M, Seetharaman, J, Belote, R.L, Foote, E.L, Ciccosanti, C, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-03-20 | Release date: | 2009-03-31 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Crystal structure of the leucine-rich repeat-containing protein LegL7 from Legionella pneumophila. Northeast Structural Genomics Consortium target LgR148. To be Published
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5OCG
| Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method. | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, GTPase KRas, ... | Authors: | Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H. | Deposit date: | 2017-06-30 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
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7QPD
| Structure of the human MHC I peptide-loading complex editing module | Descriptor: | Beta-2-microglobulin, Calreticulin, HLA class I histocompatibility antigen, ... | Authors: | Domnick, A, Susac, L, Trowitzsch, S, Thomas, C, Tampe, R. | Deposit date: | 2022-01-03 | Release date: | 2022-07-20 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Molecular basis of MHC I quality control in the peptide loading complex. Nat Commun, 13, 2022
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6QJA
| Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Nuclear mitotic apparatus protein 1 | Authors: | Renna, C, Rizzelli, F, Carminati, M, Gaddoni, C, Pirovano, L, Cecatiello, V, Pasqualato, S, Mapelli, M. | Deposit date: | 2019-01-23 | Release date: | 2020-02-05 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions. Structure, 28, 2020
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7CND
| NCI-1 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-07-31 | Release date: | 2021-06-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1. J.Med.Chem., 64, 2021
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5NXD
| LIM Domain Kinase 2 (LIMK2) In Complex With TH-300 | Descriptor: | 1,2-ETHANEDIOL, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, LIM domain kinase 2 | Authors: | Mathea, S, Salah, E, Hanke, T, Newman, J.A, Oerum, S, Wang, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Knapp, S. | Deposit date: | 2017-05-10 | Release date: | 2017-05-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | LIM Domain Kinase 2 (LIMK2)In Complex With TH-300 To Be Published
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7COW
| 353 bp di-nucleosome harboring cohesive DNA termini with linker histone H1.0 | Descriptor: | CALCIUM ION, CHLORIDE ION, DNA (353-MER), ... | Authors: | Adhireksan, Z, Sharma, D, Lee, P.L, Davey, C.A. | Deposit date: | 2020-08-05 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
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5OB2
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7QWJ
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5M6C
| CRYSTAL STRUCTURE OF T71N MUTANT OF HUMAN HIPPOCALCIN | Descriptor: | CALCIUM ION, Neuron-specific calcium-binding protein hippocalcin | Authors: | Helassa, N, Antonyuk, S.V, Lian, L.Y, Haynes, L.P, Burgoyne, R.D. | Deposit date: | 2016-10-24 | Release date: | 2017-04-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Hum. Mol. Genet., 26, 2017
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3HP3
| Crystal structure of CXCL12 | Descriptor: | CXCL12 protein, GOLD ION | Authors: | Murphy, J.W, Lolis, E, Xiong, Y, Yuan, H, Crichlow, G. | Deposit date: | 2009-06-03 | Release date: | 2010-01-26 | Last modified: | 2018-05-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family Proteins, 78, 2009
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5O8K
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5OAV
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7ROV
| KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903 | Descriptor: | Cyclic peptide MP-9903, GLYCEROL, Isoform 2B of GTPase KRas, ... | Authors: | Orth, P. | Deposit date: | 2021-08-02 | Release date: | 2021-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling. Chem Sci, 12, 2021
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7RSE
| NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | Authors: | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
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7RSC
| NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | Authors: | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | Deposit date: | 2021-08-11 | Release date: | 2021-09-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. Chem Sci, 12, 2021
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7DBG
| Yeast CRM1e (apo) in complex with Ran-RanBP1 | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Sun, Q, Lei, Y. | Deposit date: | 2020-10-20 | Release date: | 2021-09-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
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7R04
| Neurofibromin in open conformation | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform I of Neurofibromin | Authors: | Chaker-Margot, M, Scheffzek, K, Maier, T. | Deposit date: | 2022-02-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of activation of the tumor suppressor protein neurofibromin. Mol.Cell, 82, 2022
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7R03
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7DN9
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7DN8
| Crystal structure of Salmonella effector SopF in complex with ARF1 | Descriptor: | ADP-ribosylation factor 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ding, J, Shao, F. | Deposit date: | 2020-12-09 | Release date: | 2021-12-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6084 Å) | Cite: | ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy. Nat.Struct.Mol.Biol., 29, 2022
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7R24
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7R5K
| Human nuclear pore complex (constricted) | Descriptor: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | Authors: | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | Deposit date: | 2022-02-10 | Release date: | 2022-06-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (12 Å) | Cite: | AI-based structure prediction empowers integrative structural analysis of human nuclear pores. Science, 376, 2022
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7R5J
| Human nuclear pore complex (dilated) | Descriptor: | Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... | Authors: | Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. | Deposit date: | 2022-02-10 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (50 Å) | Cite: | AI-based structure prediction empowers integrative structural analysis of human nuclear pores Science, 376, 2022
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7R4H
| phospho-STING binding to adaptor protein complex-1 | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Xu, P, Ablasser, A. | Deposit date: | 2022-02-08 | Release date: | 2022-09-14 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (2.34 Å) | Cite: | Clathrin-associated AP-1 controls termination of STING signalling. Nature, 610, 2022
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