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7SQ2
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BU of 7sq2 by Molmil
Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ...
Authors:Endo-Streeter, S.T, Sondek, J, Harden, T.K.
Deposit date:2021-11-04
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex
Science, 330, 2010
7T8T
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BU of 7t8t by Molmil
CryoEM structure of PLCg1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION
Authors:Endo-Streeter, S, Sondek, J.
Deposit date:2021-12-17
Release date:2022-12-21
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:CryoEM structure of PLCg1
To Be Published
7Z3J
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BU of 7z3j by Molmil
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Pinotsis, N, Bunney, T.D, Katan, M.
Deposit date:2022-03-02
Release date:2022-07-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
8EMV
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BU of 8emv by Molmil
Phospholipase C beta 3 (PLCb3) in solution
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMW
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BU of 8emw by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMX
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BU of 8emx by Molmil
Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2022-09-28
Release date:2023-05-24
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8T7C
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BU of 8t7c by Molmil
Crystal structure of human phospholipase C gamma 2
Descriptor: 1,2-ETHANEDIOL, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, CALCIUM ION
Authors:Chen, Y, Choi, H, Zhuang, N, Hu, L, Qian, D, Wang, J.
Deposit date:2023-06-20
Release date:2024-06-26
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
To Be Published
8UQO
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BU of 8uqo by Molmil
PLCb3-Gbg-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8UQN
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BU of 8uqn by Molmil
PLCb3-Gaq complex on membranes
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Falzone, M.E, MacKinnon, R.
Deposit date:2023-10-24
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
9BCZ
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BU of 9bcz by Molmil
Chicken 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) in complex with calcium and phosphorylated threonine
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Edwards, M.M, Dong, A, Theo-Emegano, N, Seitova, A, Loppnau, P, Leung, R, Li, H, Ilyassov, O, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2024-04-10
Release date:2024-05-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Chicken 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1) in complex with calcium and phosphorylated threonine
To be published
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數據於2024-10-30公開中

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