4J2T
 
 | | Inhibitor-bound Ca2+ ATPase | | Descriptor: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, ... | | Authors: | Paulsen, E.S, Villadsen, J, Tenori, E, Liu, H, Lie, M.A, Bonde, D.F, Bublitz, M, Olesen, C, Autzen, H.E, Dach, I, Sehgal, P, Moller, J.V, Schiott, B, Nissen, P, Christensen, S.B. | | Deposit date: | 2013-02-05 | | Release date: | 2013-06-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase.
J.Med.Chem., 56, 2013
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5NCQ
 | | Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP | | Descriptor: | (1~{S})-~{N}-[(4-bromophenyl)methyl]-7-(trifluoromethyloxy)-2,3,4,9-tetrahydro-1~{H}-carbazol-1-amine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM ION, ... | | Authors: | Bublitz, M, Kjellerup, L, O'Hanlon Cohrt, K, Gordon, S, Mortensen, A.L, Clausen, J.D, Pallin, D, Hansen, J.B, Brown, W.D, Fuglsang, A, Winther, A.-M.L. | | Deposit date: | 2017-03-06 | | Release date: | 2018-01-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity.
PLoS ONE, 13, 2018
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1T5T
 | | Structure of the (SR)Ca2+-ATPase Ca2-E1-ADP:AlF4- form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Sorensen, T.L.-M, Moller, J.V, Nissen, P. | | Deposit date: | 2004-05-05 | | Release date: | 2004-06-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Phosphoryl transfer and calcium ion occlusion in the calcium pump.
Science, 304, 2004
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1VFP
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6JXJ
 | | Rb+-bound E2-AlF state of the gastric proton pump (Tyr799Trp) | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Abe, K, Irie, K. | | Deposit date: | 2019-04-23 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A single K + -binding site in the crystal structure of the gastric proton pump.
Elife, 8, 2019
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6K7G
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
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6K7L
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state class2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-03 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
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6JXK
 | | Rb+-bound E2-MgF state of the gastric proton pump (Wild-type) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, MAGNESIUM ION, ... | | Authors: | Abe, K, Irie, K, Yamamoto, K. | | Deposit date: | 2019-04-23 | | Release date: | 2019-08-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | A single K + -binding site in the crystal structure of the gastric proton pump.
Elife, 8, 2019
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6K7M
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2Pi-PL state) | | Descriptor: | (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | Deposit date: | 2019-06-07 | | Release date: | 2019-08-28 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
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3J08
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3IXZ
 | | Pig gastric H+/K+-ATPase complexed with aluminium fluoride | | Descriptor: | Potassium-transporting ATPase alpha, Potassium-transporting ATPase subunit beta | | Authors: | Abe, K, Tani, K, Nishizawa, T, Fujiyoshi, Y. | | Deposit date: | 2009-03-09 | | Release date: | 2009-06-23 | | Last modified: | 2024-02-21 | | Method: | ELECTRON CRYSTALLOGRAPHY (6.5 Å) | | Cite: | Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle
Embo J., 28, 2009
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8D3Y
 | | Human alpha3 Na+/K+-ATPase in its exoplasmic side-open state | | Descriptor: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1 | | Authors: | Nguyen, P.T, Bai, X. | | Deposit date: | 2022-06-01 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for gating mechanism of the human sodium-potassium pump.
Nat Commun, 13, 2022
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8D3X
 | | Human alpha3 Na+/K+-ATPase in its K+-occluded state | | Descriptor: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1, ... | | Authors: | Nguyen, P.T, Bai, X. | | Deposit date: | 2022-06-01 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for gating mechanism of the human sodium-potassium pump.
Nat Commun, 13, 2022
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8D3U
 | | Human alpha3 Na+/K+-ATPase in its Na+-occluded state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, ... | | Authors: | Nguyen, P.T, Bai, X. | | Deposit date: | 2022-06-01 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for gating mechanism of the human sodium-potassium pump.
Nat Commun, 13, 2022
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8D3W
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8D3V
 | | Human alpha3 Na+/K+-ATPase in its cytoplasmic side-open state | | Descriptor: | FXYD domain-containing ion transport regulator 6, Sodium/potassium-transporting ATPase subunit alpha-3, Sodium/potassium-transporting ATPase subunit beta-1 | | Authors: | Nguyen, P.T, Bai, X. | | Deposit date: | 2022-06-01 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for gating mechanism of the human sodium-potassium pump.
Nat Commun, 13, 2022
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3J09
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3KDP
 | | Crystal structure of the sodium-potassium pump | | Descriptor: | CHOLESTEROL, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ... | | Authors: | Morth, J.P, Pedersen, B.P, Nissen, P. | | Deposit date: | 2009-10-23 | | Release date: | 2010-02-16 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of the sodium-potassium pump.
Nature, 450, 2007
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3J7T
 | | Calcium atpase structure with two bound calcium ions determined by electron crystallography of thin 3D crystals | | Descriptor: | CALCIUM ION, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | | Authors: | Yonekura, K, Kato, K, Ogasawara, M, Tomita, M, Toyoshima, C. | | Deposit date: | 2014-08-07 | | Release date: | 2015-02-18 | | Last modified: | 2016-09-28 | | Method: | ELECTRON CRYSTALLOGRAPHY (3.4 Å) | | Cite: | Electron crystallography of ultrathin 3D protein crystals: atomic model with charges
Proc.Natl.Acad.Sci.USA, 112, 2015
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7R0H
 | | STRUCTURAL BASIS OF ION UPTAKE IN COPPER-TRANSPORTING P1B-TYPE ATPASES | | Descriptor: | COPPER (II) ION, Putative copper-exporting P-type ATPase A | | Authors: | Salustros, N, Groenberg, C, Wang, K, Gourdon, P. | | Deposit date: | 2022-02-02 | | Release date: | 2022-09-14 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | Structural basis of ion uptake in copper-transporting P 1B -type ATPases.
Nat Commun, 13, 2022
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7R0I
 | | STRUCTURAL BASIS OF ION UPTAKE IN COPPER-TRANSPORTING P1B-TYPE ATPASES | | Descriptor: | MAGNESIUM ION, POTASSIUM ION, Putative copper-exporting P-type ATPase A | | Authors: | Salustros, N, Groenberg, C, Wang, K, Gourdon, P. | | Deposit date: | 2022-02-02 | | Release date: | 2022-09-14 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of ion uptake in copper-transporting P 1B -type ATPases.
Nat Commun, 13, 2022
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7R0G
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3W5B
 | | Crystal structure of the recombinant SERCA1a (calcium pump of fast twitch skeletal muscle) in the E1.Mg2+ state | | Descriptor: | 2',3'-O-[(1r)-2,4,6-trinitrocyclohexa-2,5-diene-1,1-diyl]adenosine 5'-(dihydrogen phosphate), MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | | Authors: | Toyoshima, C, Iwasawa, S, Ogawa, H, Hirata, A, Tsueda, J, Inesi, G. | | Deposit date: | 2013-01-27 | | Release date: | 2013-03-06 | | Last modified: | 2013-03-27 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
Nature, 495, 2013
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4XOU
 | | Crystal structure of the SR Ca2+-ATPase in the Ca2-E1-MgAMPPCP form determined by serial femtosecond crystallography using an X-ray free-electron laser. | | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ... | | Authors: | Bublitz, M, Nass, K, Drachmann, N.D, Markvardsen, A.J, Gutmann, M.J, Barends, T.R.M, Mattle, D, Shoeman, R.L, Doak, R.B, Boutet, S, Messerschmidt, M, Seibert, M.M, Williams, G.J, Foucar, L, Reinhard, L, Sitsel, O, Gregersen, J.L, Clausen, J.D, Boesen, T, Gotfryd, K, Wang, K.-T, Olesen, C, Moller, J.V, Nissen, P, Schlichting, I. | | Deposit date: | 2015-01-16 | | Release date: | 2015-06-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural studies of P-type ATPase-ligand complexes using an X-ray free-electron laser.
Iucrj, 2, 2015
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4XE5
 | | Crystal structure of the Na,K-ATPase from bovine | | Descriptor: | CHOLESTEROL, MAGNESIUM ION, OUABAIN, ... | | Authors: | Gregersen, J.L, Mattle, D, Fedosova, N.U, Nissen, P, Reinhard, L. | | Deposit date: | 2014-12-22 | | Release date: | 2016-03-09 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.901 Å) | | Cite: | Isolation, crystallization and crystal structure determination of bovine kidney Na(+),K(+)-ATPase.
Acta Crystallogr.,Sect.F, 72, 2016
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