5NCQ
Structure of the (SR) Ca2+-ATPase bound to a Tetrahydrocarbazole and TNP-ATP
Summary for 5NCQ
Entry DOI | 10.2210/pdb5ncq/pdb |
Descriptor | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | p-type atpase, inhibitory complex, calcium-transporting atpase, hydrolase |
Biological source | Oryctolagus cuniculus (Rabbit) |
Cellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein : P04191 |
Total number of polymer chains | 1 |
Total formula weight | 112373.46 |
Authors | Bublitz, M.,Kjellerup, L.,O'Hanlon Cohrt, K.,Gordon, S.,Mortensen, A.L.,Clausen, J.D.,Pallin, D.,Hansen, J.B.,Brown, W.D.,Fuglsang, A.,Winther, A.-M.L. (deposition date: 2017-03-06, release date: 2018-01-10, Last modification date: 2024-01-17) |
Primary citation | Bublitz, M.,Kjellerup, L.,Cohrt, K.O.,Gordon, S.,Mortensen, A.L.,Clausen, J.D.,Pallin, T.D.,Hansen, J.B.,Fuglsang, A.T.,Dalby-Brown, W.,Winther, A.L. Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity. PLoS ONE, 13:e0188620-e0188620, 2018 Cited by PubMed: 29293507DOI: 10.1371/journal.pone.0188620 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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