5M95
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![BU of 5m95 by Molmil](/molmil-images/mine/5m95) | STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE | Descriptor: | CAMELID ANTIBODY FRAGMENT, NANOBODY, Divalent metal cation transporter MntH, ... | Authors: | Ehrnstorfer, I.A, Geertsma, E.R, Pardon, E, Steyaert, J, Dutzler, R. | Deposit date: | 2016-10-31 | Release date: | 2016-11-30 | Last modified: | 2019-09-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure Of A Slc11 (Nramp) Transporter Reveals The Basis For Transition-Metal Ion Transport. Nat.Struct.Mol.Biol., 21, 2014
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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8VYE
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![BU of 8vye by Molmil](/molmil-images/mine/8vye) | SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, S2L20 Light Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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8VYG
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![BU of 8vyg by Molmil](/molmil-images/mine/8vyg) | SARS-CoV-2 S RBD (C.37 Lambda variant) plus S309 Fab, local refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Heavy Chain, S309 Light Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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8VYF
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![BU of 8vyf by Molmil](/molmil-images/mine/8vyf) | SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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5FUU
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![BU of 5fuu by Molmil](/molmil-images/mine/5fuu) | Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lee, J.H, Ward, A.B. | Deposit date: | 2016-01-29 | Release date: | 2016-03-09 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-Em Structure of a Native, Fully Glycosylated and Cleaved HIV-1 Envelope Trimer Science, 351, 2016
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5NJD
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![BU of 5njd by Molmil](/molmil-images/mine/5njd) | Structure of Interleukin 23 in complex with Briakinumab FAb | Descriptor: | Briakinumab FAb Heavy chain, Briakinumab FAb Light chain, Interleukin-12 subunit beta, ... | Authors: | Bloch, Y, Savvides, S.N. | Deposit date: | 2017-03-28 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1. Immunity, 48, 2018
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4M48
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![BU of 4m48 by Molmil](/molmil-images/mine/4m48) | X-ray structure of dopamine transporter elucidates antidepressant mechanism | Descriptor: | 9D5 antibody, heavy chain, light chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2013-08-06 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature, 503, 2013
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6UGU
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![BU of 6ugu by Molmil](/molmil-images/mine/6ugu) | Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a C-centered orthorhombic crystal form, Lot C | Descriptor: | PF06438179 Fab Heavy Chain, PF06438179 Fab Light Chain | Authors: | Lerch, T.F, Sharpe, P, Mayclin, S.J, Edwards, T.E, Polleck, S, Rouse, J.C, Conlan, H.D. | Deposit date: | 2019-09-26 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar. BioDrugs, 34, 2020
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5HYI
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![BU of 5hyi by Molmil](/molmil-images/mine/5hyi) | Glycosylated, disulfide-linked Hole-Hole Fc fragment | Descriptor: | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Kuglstatter, A, Stihle, M, Benz, J. | Deposit date: | 2016-02-01 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products. Protein Eng. Des. Sel., 30, 2017
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1SJV
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![BU of 1sjv by Molmil](/molmil-images/mine/1sjv) | Three-Dimensional Structure of a Llama VHH Domain Swapping | Descriptor: | r9 | Authors: | Spinelli, S, Desmyter, A, Frenken, L, Verrips, T, Cambillau, C. | Deposit date: | 2004-03-04 | Release date: | 2004-06-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet structure. Febs Lett., 564, 2004
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2QL1
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![BU of 2ql1 by Molmil](/molmil-images/mine/2ql1) | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | Descriptor: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2007-07-12 | Release date: | 2008-04-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.534 Å) | Cite: | Structural characterization of a mutated, ADCC-enhanced human Fc fragment Mol.Immunol., 45, 2008
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7RAQ
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![BU of 7raq by Molmil](/molmil-images/mine/7raq) | |
3QO1
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![BU of 3qo1 by Molmil](/molmil-images/mine/3qo1) | Monoclinic form of IgG1 Fab fragment (apo form) sharing same Fv as IgA | Descriptor: | Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN, Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN, GLYCEROL | Authors: | Trajtenberg, F, Correa, A, Buschiazzo, A. | Deposit date: | 2011-02-09 | Release date: | 2012-02-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a human IgA1 Fab fragment at 1.55 angstrom resolution: potential effect of the constant domains on antigen-affinity modulation Acta Crystallogr.,Sect.D, 69, 2013
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7D2Z
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![BU of 7d2z by Molmil](/molmil-images/mine/7d2z) | Structure of sybody SR31 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) | Descriptor: | ACETATE ION, FORMIC ACID, GLYCEROL, ... | Authors: | Li, T, Cai, H, Yao, H, Qin, W, Li, D. | Deposit date: | 2020-09-17 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2. Plos Pathog., 17, 2021
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7D30
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![BU of 7d30 by Molmil](/molmil-images/mine/7d30) | Structure of sybody MR17-SR31 fusion in complex with the SARS-CoV-2 S Receptor Binding domain (RBD) | Descriptor: | 1,3-BUTANEDIOL, ACETATE ION, CADMIUM ION, ... | Authors: | Li, T, Yao, H, Cai, H, Qin, W, Li, D. | Deposit date: | 2020-09-17 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2. Plos Pathog., 17, 2021
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8TJR
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![BU of 8tjr by Molmil](/molmil-images/mine/8tjr) | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody HERH-a.01 Heavy Chain, ... | Authors: | Morano, N.C, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L. | Deposit date: | 2023-07-24 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB To Be Published
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1GHF
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![BU of 1ghf by Molmil](/molmil-images/mine/1ghf) | ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT | Descriptor: | ANTI-ANTI-IDIOTYPE GH1002 FAB FRAGMENT | Authors: | Ban, N, Day, J, Wang, X, Ferrone, S, McPherson, A. | Deposit date: | 1995-11-30 | Release date: | 1996-12-23 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of an anti-anti-idiotype shows it to be self-complementary. J.Mol.Biol., 255, 1996
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8TUZ
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![BU of 8tuz by Molmil](/molmil-images/mine/8tuz) | Fab 857-2 in complex with OspA | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy chain of human monoclonal antibody 857-2, ... | Authors: | Rudolph, M.J, Mantis, N. | Deposit date: | 2023-08-17 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.186 Å) | Cite: | Fab 857-2 in complex with OspA To Be Published
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5VKK
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![BU of 5vkk by Molmil](/molmil-images/mine/5vkk) | |
5VKE
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![BU of 5vke by Molmil](/molmil-images/mine/5vke) | Open conformation of KcsA deep-inactivated | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... | Authors: | Cuello, L.G, Perozo, E, Cortes, D.M. | Deposit date: | 2017-04-21 | Release date: | 2017-12-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
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6Z2M
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![BU of 6z2m by Molmil](/molmil-images/mine/6z2m) | H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 antibody, Spike glycoprotein, ... | Authors: | Naismith, J.H, Ren, J, Zhou, D, Zhao, Y, Stuart, D.I. | Deposit date: | 2020-05-17 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural characterisation of a nanobody derived from a naive library that neutralises SARS-CoV-2 To Be Published
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3V0A
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![BU of 3v0a by Molmil](/molmil-images/mine/3v0a) | 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | Authors: | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | Deposit date: | 2011-12-07 | Release date: | 2012-03-14 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
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6IC3
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![BU of 6ic3 by Molmil](/molmil-images/mine/6ic3) | AL amyloid fibril from a lambda 1 light chain | Descriptor: | lambda 1 light chain fragment, residues 3-118 | Authors: | Fritz, G, Faendrich, M, Schmidt, M, Radamaker, L. | Deposit date: | 2018-12-02 | Release date: | 2019-04-03 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis. Nat Commun, 10, 2019
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7CGW
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![BU of 7cgw by Molmil](/molmil-images/mine/7cgw) | Complex structure of PD-1 and tislelizumab Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, ... | Authors: | Hong, Y, Feng, Y.C, Liu, Y. | Deposit date: | 2020-07-02 | Release date: | 2021-04-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. Febs Open Bio, 11, 2021
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