6UGU

Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a C-centered orthorhombic crystal form, Lot C

Summary for 6UGU

• Entry DOI: 10.2210/pdb6ugu/pdb
• Descriptor: PF06438179 Fab Heavy Chain, PF06438179 Fab Light Chain (3 entities in total)
• Functional Keywords: antibody, fab, infliximab, biosimilar, tnfa, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 95634.10

Authors

Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Conlan, H.D. (deposition date: 2019-09-26, release date: 2019-11-13, Last modification date: 2023-10-11)

• Primary citation: Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Polleck, S.,Rouse, J.C.,Zou, Q.,Conlon, H.D.; Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.; BioDrugs, 34:77-87, 2020; PubMed: 31650490; DOI: 10.1007/s40259-019-00390-1

Experimental method

X-RAY DIFFRACTION (2.2 Å)