7P03
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![BU of 7p03 by Molmil](/molmil-images/mine/7p03) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation without nucleotides | Descriptor: | Pleiotropic ABC efflux transporter of multiple drugs | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P04
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![BU of 7p04 by Molmil](/molmil-images/mine/7p04) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs | Authors: | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | Deposit date: | 2021-06-29 | Release date: | 2021-11-10 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
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7P00
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![BU of 7p00 by Molmil](/molmil-images/mine/7p00) | Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7P02
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![BU of 7p02 by Molmil](/molmil-images/mine/7p02) | Human Neurokinin 1 receptor (NK1R) substance P Gs complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7R9L
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![BU of 7r9l by Molmil](/molmil-images/mine/7r9l) | Crystal structure of HPK1 in complex with compound 2 | Descriptor: | 2-amino-N,N-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, Hematopoietic progenitor kinase | Authors: | Wu, P, Lehoux, I, Wang, W. | Deposit date: | 2021-06-29 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.332 Å) | Cite: | Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
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7R9P
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![BU of 7r9p by Molmil](/molmil-images/mine/7r9p) | Crystal structure of HPK1 in complex with compound 14 | Descriptor: | 6-amino-2-fluoro-N,N-dimethyl-3-(4'-methylspiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)benzamide, Hematopoietic progenitor kinase, SULFATE ION | Authors: | Wu, P, Lehoux, I, Wang, W. | Deposit date: | 2021-06-29 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
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7R9T
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![BU of 7r9t by Molmil](/molmil-images/mine/7r9t) | Crystal structure of HPK1 in complex with compound 17 | Descriptor: | 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide, Hematopoietic progenitor kinase | Authors: | Wu, P, Lehoux, I, Wang, W. | Deposit date: | 2021-06-29 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
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7R9N
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![BU of 7r9n by Molmil](/molmil-images/mine/7r9n) | Crystal structure of HPK1 in complex with GNE1858 | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hematopoietic progenitor kinase, ... | Authors: | Wu, P, Lehoux, I, Wang, W. | Deposit date: | 2021-06-29 | Release date: | 2022-01-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13, 2022
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7RA3
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![BU of 7ra3 by Molmil](/molmil-images/mine/7ra3) | cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP | Descriptor: | Gastric inhibitory polypeptide, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | Deposit date: | 2021-06-29 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7R94
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![BU of 7r94 by Molmil](/molmil-images/mine/7r94) | T-Plastin-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Alushin, G.M. | Deposit date: | 2021-06-28 | Release date: | 2022-07-06 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural mechanism for bidirectional actin cross-linking by T-plastin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7R97
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![BU of 7r97 by Molmil](/molmil-images/mine/7r97) | Crystal structure of postcleavge complex of Escherichia coli RNase III | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Dharavath, S, Shaw, G.X, Ji, X. | Deposit date: | 2021-06-28 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg 2+ -ion catalysis. Rna Biol., 19, 2022
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7R91
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![BU of 7r91 by Molmil](/molmil-images/mine/7r91) | cryo-EM structure of the rigor state wild type myosin-15-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-06-28 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7OZW
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![BU of 7ozw by Molmil](/molmil-images/mine/7ozw) | |
7OZJ
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![BU of 7ozj by Molmil](/molmil-images/mine/7ozj) | |
7OZI
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![BU of 7ozi by Molmil](/molmil-images/mine/7ozi) | |
7OZK
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![BU of 7ozk by Molmil](/molmil-images/mine/7ozk) | CryoEM structure of human enterovirus 70 in complex with Pleconaril | Descriptor: | 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, Capsid protein VP1, Capsid protein VP2, ... | Authors: | Fuzik, T, Plevka, P, Moravcova, J. | Deposit date: | 2021-06-28 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.31 Å) | Cite: | Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
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7OZL
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![BU of 7ozl by Molmil](/molmil-images/mine/7ozl) | CryoEM structure of human enterovirus 70 in complex with WIN51711 | Descriptor: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, Capsid protein VP1, Capsid protein VP2, ... | Authors: | Fuzik, T, Plevka, P, Moravcova, J. | Deposit date: | 2021-06-28 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. J.Virol., 96, 2022
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7R8U
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![BU of 7r8u by Molmil](/molmil-images/mine/7r8u) | |
7R8S
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7R8T
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![BU of 7r8t by Molmil](/molmil-images/mine/7r8t) | |
7R8V
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![BU of 7r8v by Molmil](/molmil-images/mine/7r8v) | Cryo-EM structure of the ADP state actin filament | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Gong, R, Espinosa de los Reyes, S, Reynolds, M.J, Gurel, P, Alushin, G.M. | Deposit date: | 2021-06-27 | Release date: | 2021-07-28 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7R8W
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![BU of 7r8w by Molmil](/molmil-images/mine/7r8w) | |
7R8X
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![BU of 7r8x by Molmil](/molmil-images/mine/7r8x) | |
7R8D
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![BU of 7r8d by Molmil](/molmil-images/mine/7r8d) | The structure of human ABCG1 E242Q with cholesterol | Descriptor: | CHOLESTEROL, Isoform 4 of ATP-binding cassette sub-family G member 1 | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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7R8A
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![BU of 7r8a by Molmil](/molmil-images/mine/7r8a) | The structure of human ABCG5/ABCG8 purified from mammalian cells | Descriptor: | 2C7 Fab heavy chain, 2C7 Fab light chain, ATP-binding cassette sub-family G member 5, ... | Authors: | Sun, Y, Li, X, Long, T. | Deposit date: | 2021-06-26 | Release date: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis of cholesterol efflux via ABCG subfamily transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
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