7OZW

Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with fragment 166 at the transient P-pocket

Summary for 7OZW

• Entry DOI: 10.2210/pdb7ozw/pdb
• EMDB information: 13139
• Descriptor: Reverse transcriptase/ribonuclease H, DNA (37-MER), (1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl)cyclopropane-1-carboxamide, ... (4 entities in total)
• Functional Keywords: reverse transcriptase, rt-aptamer complex, rt sliding, p-1 complex, p51, p66, transferase
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 3
• Total formula weight: 125765.53

Authors

Singh, A.K.,Das, K. (deposition date: 2021-06-28, release date: 2021-12-08, Last modification date: 2021-12-22)

• Primary citation: Singh, A.K.,Martinez, S.E.,Gu, W.,Nguyen, H.,Schols, D.,Herdewijn, P.,De Jonghe, S.,Das, K.; Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening.; Nat Commun, 12:7127-7127, 2021; PubMed: 34880240; DOI: 10.1038/s41467-021-27409-y

Experimental method

ELECTRON MICROSCOPY (3.38 Å)