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7OZW

Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with fragment 166 at the transient P-pocket

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AReverse transcriptase/ribonuclease Hpolymer55664047.41UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Pfam (PF00075)
In PDB
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)Exoribonuclease H,p66 RT
2BReverse transcriptase/ribonuclease Hpolymer42850039.51UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
In PDB
Human immunodeficiency virus type 1 BH10 (HIV-1)Exoribonuclease H,p51 RT
3FDNA (37-MER)polymer3711434.31synthetic construct
4A(1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl)cyclopropane-1-carboxamidenon-polymer244.31Chemie (3IR)
Sequence modifications
A: 1 - 554 (UniProt: P03366)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Val 0-expression tag
Ser 280Cys 879engineered mutation
Asn 498Asp 1097engineered mutation
B: 1 - 428 (UniProt: P03366)
PDBExternal DatabaseDetails
Ser 280Cys 879engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight125521.2
Non-Polymers*Number of molecules1
Total formula weight244.3
All*Total formula weight125765.5
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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