7R9T

Crystal structure of HPK1 in complex with compound 17

Summary for 7R9T

Entry DOI	10.2210/pdb7r9t/pdb
Descriptor	Hematopoietic progenitor kinase, 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide (3 entities in total)
Functional Keywords	kinase, inhibitor, map4k1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	67222.64
Authors	Wu, P.,Lehoux, I.,Wang, W. (deposition date: 2021-06-29, release date: 2022-01-05, Last modification date: 2023-10-18)
Primary citation	Chan, B.K.,Seward, E.,Lainchbury, M.,Brewer, T.F.,An, L.,Blench, T.,Cartwright, M.W.,Chan, G.K.Y.,Choo, E.F.,Drummond, J.,Elliott, R.L.,Gancia, E.,Gazzard, L.,Hu, B.,Jones, G.E.,Luo, X.,Madin, A.,Malhotra, S.,Moffat, J.G.,Pang, J.,Salphati, L.,Sneeringer, C.J.,Stivala, C.E.,Wei, B.,Wang, W.,Wu, P.,Heffron, T.P. Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). Acs Med.Chem.Lett., 13:84-91, 2022 Cited by PubMed: 35059127 DOI: 10.1021/acsmedchemlett.1c00473 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation