7R9T
Crystal structure of HPK1 in complex with compound 17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hematopoietic progenitor kinase | polymer | 297 | 33206.5 | 2 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (Human) | HKP1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1 |
| 2 | C, D (A, B) | 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide | non-polymer | 404.9 | 2 | Chemie (2TR) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 654 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 293 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
| Gly 294 | - | expression tag |
| Asn 295 | - | expression tag |
| Ser 296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66412.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 809.7 | |
| All* | Total formula weight | 67222.6 |
