7R9T
Crystal structure of HPK1 in complex with compound 17
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Hematopoietic progenitor kinase | polymer | 297 | 33206.5 | 2 | UniProt (Q92918) Pfam (PF00069) In PDB | Homo sapiens (Human) | HKP1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1 |
2 | A, B | 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide | non-polymer | 404.9 | 2 | Chemie (2TR) | |||
3 | water | water | 18.0 | 654 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 293 (UniProt: Q92918)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
Glu 165 | Thr 165 | conflict |
Glu 171 | Ser 171 | conflict |
Gly 294 | - | expression tag |
Asn 295 | - | expression tag |
Ser 296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66412.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 809.7 | |
All* | Total formula weight | 67222.6 |