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8ISP	Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by cephalexin Descriptor: (R)-2-((R)-((R)-2-amino-2-phenylacetamido)(carboxy)methyl)-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase Authors: Jeong, B.G, Kim, M.Y, Jeong, C.S, Do, H.W, Lee, J.H, Cha, S.S. Deposit date: 2023-03-21 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference. Int J Antimicrob Agents, 63, 2024
8ISQ	Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by ampicillin Descriptor: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, ... Authors: Jeong, B.G, Kim, M.Y, Jeong, C.S, Do, H.W, Lee, J.H, Cha, S.S. Deposit date: 2023-03-21 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference. Int J Antimicrob Agents, 63, 2024
8ISR	Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by cefaclor Descriptor: (R)-2-((R)-((R)-2-amino-2-phenylacetamido)(carboxy)methyl)-5-chloro-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase Authors: Jeong, B.G, Kim, M.Y, Jeong, C.S, Do, H.W, Lee, J.H, Cha, S.S. Deposit date: 2023-03-21 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference. Int J Antimicrob Agents, 63, 2024
8J6Y	Crystal structure of class A beta-lactamase PSE-4 WT- Apo state Descriptor: Beta-lactamase PSE-4, SULFATE ION Authors: Sarkar, M, Bhattacharya, S, Hazra, S. Deposit date: 2023-04-26 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of class A beta-lactamase PSE-4 WT- Apo state To be published
8IWV	Crystal structure of BlaA-1 APO Descriptor: Beta-lactamase, PHOSPHATE ION Authors: Bhattacharya, S, Hazra, S. Deposit date: 2023-03-31 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of BlaA-1 APO To be published
8IX8	Crystal structure of Class A beta-lactamase BlaA WT - complex with Tebipenem Descriptor: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION Authors: Bhattacharya, S, Hazra, S. Deposit date: 2023-03-31 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of Class A beta-lactamase BlaA WT - complex with Tebipenem To be published
8IXX	Crystal structure of Class A beta-lactamase BlaA WT - complex with Ertapenem Descriptor: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION Authors: Bhattacharya, S, Hazra, S. Deposit date: 2023-04-03 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Class A beta-lactamase BlaA WT - complex with Ertapenem To be published
8IY4	Crystal structure of Class A beta-lactamase BlaA WT - complex with Meropenem Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION Authors: Bhattacharya, S, Hazra, S. Deposit date: 2023-04-03 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of Class A beta-lactamase BlaA WT - complex with Meropenem To be published
8JK3	Crystal Structure of Bel-1 Extended Spectrum Beta-lactamase in Hexagonal Form Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Beta-lactamase, ... Authors: Dhankhar, K, Hazra, S. Deposit date: 2023-05-31 Release date: 2024-06-05 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of Bel-1 ESBL in Hexagonal Form To Be Published
8JOI	Crystal Structure of Bel-1 E166A Mutant. Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BROMIDE ION, Beta-lactamase, ... Authors: Dhankhar, K, Hazra, S. Deposit date: 2023-06-07 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of Bel-1 E166A Mutant To Be Published
8OE1	Structure of P167S BlaC from Mycobacterium tuberculosis at pH 5 Descriptor: Beta-lactamase, GLYCEROL Authors: Sun, J, Chikunova, A, Ubbink, M. Deposit date: 2023-03-10 Release date: 2023-08-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase. Int.J.Biol.Macromol., 250, 2023
8OE5	Structure of P167S BlaC from Mycobacterium tuberculosis at pH 6.3 Descriptor: Beta-lactamase, CITRATE ANION, GLYCEROL Authors: Sun, J, Chikunova, A, Ubbink, M. Deposit date: 2023-03-10 Release date: 2023-08-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase. Int.J.Biol.Macromol., 250, 2023
8EC4	XFEL structure of Mycobacterium tuberculosis beta lactamase microcrystals mixed with sulbactam for 240ms Descriptor: Beta-lactamase, PHOSPHATE ION, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM Authors: Malla, T.N, Schmidt, M. Deposit date: 2022-09-01 Release date: 2023-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Heterogeneity in M. tuberculosis beta-lactamase inhibition by Sulbactam. Nat Commun, 14, 2023
8EBI	XFEL structure of beta lactamase microcrystals mixed with sulbactam solution for 15ms Descriptor: Beta-lactamase, PHOSPHATE ION, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM Authors: Malla, T.N, Schmidt, M. Deposit date: 2022-08-31 Release date: 2023-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Heterogeneity in M. tuberculosis beta-lactamase inhibition by Sulbactam. Nat Commun, 14, 2023
8ECF	Cryo structure of Mycobacterium tuberculosis beta lactamase microcrystals mixed with sulbactam for 3 hours Descriptor: Beta-lactamase, PHOSPHATE ION, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM Authors: Malla, T.N, Schmidt, M. Deposit date: 2022-09-01 Release date: 2023-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.736 Å) Cite: Heterogeneity in M. tuberculosis beta-lactamase inhibition by Sulbactam. Nat Commun, 14, 2023
8EBR	XFEL structure of Mycobacterium tuberculosis beta lactamase microcrystals mixed with sulbactam for 30ms Descriptor: Beta-lactamase, PHOSPHATE ION, SULBACTAM, ... Authors: Malla, T.N, Schmidt, M. Deposit date: 2022-08-31 Release date: 2023-03-08 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Heterogeneity in M. tuberculosis beta-lactamase inhibition by Sulbactam. Nat Commun, 14, 2023
8DOD	Beta-lactamase CTX-M-14 S130A Descriptor: Beta-lactamase, POTASSIUM ION Authors: Lu, S, Palzkill, T. Deposit date: 2022-07-12 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
8DOE	Crystal Structure of CTX-M-14 N106A Descriptor: Beta-lactamase Authors: Lu, S, Palzkill, T. Deposit date: 2022-07-12 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
8DP4	Beta-lactamase CTX-M-14 T235A Descriptor: Beta-lactamase Authors: Lu, S, Palzkill, T. Deposit date: 2022-07-14 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.402 Å) Cite: Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
8DON	Beta-lactamase CTX-M-14 T215A Descriptor: Beta-lactamase, PHOSPHATE ION Authors: Lu, S, Palzkill, T. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
8DPQ	Beta-lactamase CTX-M-14 N170A Descriptor: 1,2-ETHANEDIOL, Beta-lactamase Authors: Lu, S, Neetu, N, Palzkill, T. Deposit date: 2022-07-15 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
3OPH	ESBL R164S mutant of SHV-1 beta-lactamase Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE Authors: Sampson, J.M, van den Akker, F. Deposit date: 2010-09-01 Release date: 2011-07-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob.Agents Chemother., 55, 2011
3OPL	ESBL R164H mutant SHV-1 beta-lactamase Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE Authors: Sampson, J.M, van den Akker, F. Deposit date: 2010-09-01 Release date: 2011-07-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob.Agents Chemother., 55, 2011
3OPR	ESBL R164H mutant of SHV-1 beta-lactamase complexed to SA2-13 Descriptor: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE Authors: Sampson, J.M, van den Akker, F. Deposit date: 2010-09-01 Release date: 2011-07-13 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob.Agents Chemother., 55, 2011
3P98	The crystal structure of the extended spectrum beta-lactamase TEM-72 reveals inhibition by citrate Descriptor: Beta-lactamase TEM-72, CITRIC ACID, DI(HYDROXYETHYL)ETHER Authors: Docquier, J.D, Benvenuti, M, Calderone, V, Rossolini, G.M, Mangani, S. Deposit date: 2010-10-16 Release date: 2011-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the extended-spectrum [beta]-lactamase TEM-72 inhibited by citrate Acta Crystallogr.,Sect.F, 67, 2011

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