8ISP

Crystal structure of extended-spectrum class A beta-lactamase, CESS-1 E166Q acylated by cephalexin

Summary for 8ISP

• Entry DOI: 10.2210/pdb8isp/pdb
• Related: 1O7E
• Descriptor: Beta-lactamase, (R)-2-((R)-((R)-2-amino-2-phenylacetamido)(carboxy)methyl)-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
• Functional Keywords: hydrolase, extended-spectrum class a beta-lactamase
• Biological source: Stenotrophomonas sp. KCTC 12332
• Total number of polymer chains: 1
• Total formula weight: 29017.68

Authors

Jeong, B.G.,Kim, M.Y.,Jeong, C.S.,Do, H.W.,Lee, J.H.,Cha, S.S. (deposition date: 2023-03-21, release date: 2024-05-15)

• Primary citation: Jeong, B.G.,Kim, M.Y.,Jeong, C.S.,Do, H.,Hwang, J.,Lee, J.H.,Cha, S.S.; Characterization of the extended substrate spectrum of the class A beta-lactamase CESS-1 from Stenotrophomonas sp. and structure-based investigation into its substrate preference.; Int J Antimicrob Agents, 63:107171-107171, 2024; PubMed: 38588869; DOI: 10.1016/j.ijantimicag.2024.107171

Experimental method

X-RAY DIFFRACTION (2.11 Å)