8EC4

XFEL structure of Mycobacterium tuberculosis beta lactamase microcrystals mixed with sulbactam for 240ms

Summary for 8EC4

• Entry DOI: 10.2210/pdb8ec4/pdb
• Descriptor: Beta-lactamase, PHOSPHATE ION, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM, ... (4 entities in total)
• Functional Keywords: beta lactamase, sulbactam, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 114924.32

Authors

Malla, T.N.,Schmidt, M. (deposition date: 2022-09-01, release date: 2023-03-08, Last modification date: 2023-10-25)

• Primary citation: Malla, T.N.,Zielinski, K.,Aldama, L.,Bajt, S.,Feliz, D.,Hayes, B.,Hunter, M.,Kupitz, C.,Lisova, S.,Knoska, J.,Martin-Garcia, J.M.,Mariani, V.,Pandey, S.,Poudyal, I.,Sierra, R.G.,Tolstikova, A.,Yefanov, O.,Yoon, C.H.,Ourmazd, A.,Fromme, P.,Schwander, P.,Barty, A.,Chapman, H.N.,Stojkovic, E.A.,Batyuk, A.,Boutet, S.,Phillips Jr., G.N.,Pollack, L.,Schmidt, M.; Heterogeneity in M. tuberculosis beta-lactamase inhibition by Sulbactam.; Nat Commun, 14:5507-5507, 2023; PubMed: 37679343; DOI: 10.1038/s41467-023-41246-1

Experimental method

X-RAY DIFFRACTION (2.35 Å)