PDB: 37273 resultsInfo pagesStatus searchChemie searchBIRD

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4QEQ	High resolution structure of egg white lysozyme Descriptor: Lysozyme C Authors: Shaik, M.M. Deposit date: 2014-05-18 Release date: 2014-05-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.381 Å) Cite: High resolution structure of egg white Lysozyme To be Published
4QF8	Crystal Structure of the Complex of Phospholipase A2 with Spermidine at 1.65 A Resolution Descriptor: Phospholipase A2 VRV-PL-VIIIa, SPERMIDINE, SULFATE ION Authors: Shukla, P.K, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-05-20 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structures and binding studies of the complexes of phospholipase A2 with five inhibitors Biochim.Biophys.Acta, 1854, 2015
7TUY	Cryo-EM structure of GSK682753A-bound EBI2/GPR183 Descriptor: 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ... Authors: Chen, H, Huang, W, Li, X. Deposit date: 2022-02-03 Release date: 2022-04-13 Last modified: 2022-07-20 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
8D7M	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D7O	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D7P	Human Casein kinase 1 delta in complex with phosphorylated Drosophila PERIOD peptide Descriptor: Casein kinase I isoform delta, Period circadian protein peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
8D1P	Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 7-Deaza-2'-C-methyladenosine Descriptor: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Chaperone DnaK, SULFATE ION Authors: Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W. Deposit date: 2022-05-27 Release date: 2023-05-31 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.88 Å) Cite: A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
8D8P	Crystal structure of a novel fatty acid decarboxylase from Rothia nasimurium Descriptor: Decarboxylase, PALMITIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Vieira, P.S, Murakami, M.T, Zanphorlin, L.M. Deposit date: 2022-06-08 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Crystal structure of a novel fatty acid decarboxylase from Rothia nasimurium Proc.Natl.Acad.Sci.USA, 2023
5C65	Structure of the human glucose transporter GLUT3 / SLC2A3 Descriptor: CHOLESTEROL HEMISUCCINATE, Octyl Glucose Neopentyl Glycol, Solute carrier family 2, ... Authors: Pike, A.C.W, Quigley, A, Chu, A, Tessitore, A, Xia, X, Mukhopadhyay, S, Wang, D, Kupinska, K, Strain-Damerell, C, Chalk, R, Burgess-Brown, N.A, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2015-06-22 Release date: 2015-07-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of the human glucose transporter GLUT3 / SLC2A3 To Be Published
4QEM	Crystal structure of the complex of Phospholipase A2 With P-Coumaric Acid At 1.2 A Resolution Descriptor: 4'-HYDROXYCINNAMIC ACID, Phospholipase A2 VRV-PL-VIIIa, SULFATE ION Authors: Shukla, P.K, Tiwari, P, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-05-17 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structures and binding studies of the complexes of phospholipase A2 with five inhibitors Biochim.Biophys.Acta, 1854, 2015
5C6Y	A sperm whale myoglobin double mutant L29H/F43Y Mb with a Tyr-heme cross-link Descriptor: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE Authors: Yuan, H, Lin, Y.W, Tan, X.S. Deposit date: 2015-06-24 Release date: 2015-11-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.793 Å) Cite: How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobin Dalton Trans, 44, 2015
8D7N	Human Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide Descriptor: Casein kinase I isoform delta, Period circadian protein homolog 2 peptide Authors: Philpott, J.M, Freeberg, A.M, Tripathi, S.M, Partch, C.L. Deposit date: 2022-06-07 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.66 Å) Cite: PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Mol.Cell, 83, 2023
4XVR	H-Ras Y137F Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... Authors: Johnson, C.W, Mattos, C. Deposit date: 2015-01-27 Release date: 2015-06-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.031 Å) Cite: Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
5C6L	Crystal Structure of Gadolinium derivative of HEWL solved using intense Free-Electron Laser radiation Descriptor: 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ... Authors: Galli, L, Barends, T.R.M, Son, S.-K, White, T.A, Barty, A, Botha, S, Boutet, S, Caleman, C, Doak, R.B, Nanao, M.H, Nass, K, Shoeman, R.L, Timneanu, N, Santra, R, Schlichting, I, Chapman, H.N. Deposit date: 2015-06-23 Release date: 2015-07-08 Last modified: 2018-11-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Towards phasing using high X-ray intensity. Iucrj, 2, 2015
4XX3	Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide, Renin Authors: Orth, P. Deposit date: 2015-01-29 Release date: 2015-02-18 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors. Bioorg. Med. Chem. Lett., 25, 2015
8D1W	Crystal structure of Plasmodium falciparum GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol Descriptor: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Chaperone DnaK, SULFATE ION Authors: Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W, Smil, D, Zepeda, C.A.V. Deposit date: 2022-05-27 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting Plasmodium falciparum GRP78: nucleoside analogues as agents against the malaria chaperone Frontiers in Molecular Bioscience, 2022
4QGI	X-ray crystal structure of HIV-1 protease variant G48T/L89M in complex with Saquinavir Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, GLYCEROL, Protease Authors: Mahon, B.P, McKenna, R, Goldfarb, N. Deposit date: 2014-05-22 Release date: 2014-07-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.896 Å) Cite: Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency. Biochemistry, 54, 2015
5YGY	Crystal Structure of BACE1 in complex with (S)-N-(3-(2-amino-6-(fluoromethyl)-4 -methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide Descriptor: Beta-secretase 1, GLYCEROL, IODIDE ION, ... Authors: Fuchino, K, Mitsuoka, Y, Masui, M, Kurose, N, Yoshida, S, Komano, K, Yamamoto, T, Ogawa, M, Unemura, C, Hosono, M, Ito, H, Sakaguchi, G, Ando, S, Ohnishi, S, Kido, Y, Fukushima, T, Miyajima, H, Hiroyama, S, Koyabu, K, Dhuyvetter, D, Borghys, H, Gijsen, H, Yamano, Y, Iso, Y, Kusakabe, K. Deposit date: 2017-09-27 Release date: 2018-05-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Rational Design of Novel 1,3-Oxazine Based beta-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust A beta Reduction in the Brain J. Med. Chem., 61, 2018
5YIA	Crystal Structure of KNI-10343 bound Plasmepsin II (PMII) from Plasmodium falciparum Descriptor: (4R)-3-[(2S,3S)-3-[[(2R)-2-[2-(4-hydroxyphenyl)ethanoylamino]-3-methylsulfanyl-propanoyl]amino]-2-oxidanyl-4-phenyl-butanoyl]-5,5-dimethyl-N-[(1S,2R)-2-oxidanyl-2,3-dihydro-1H-inden-1-yl]-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, GLYCEROL, ... Authors: Rathore, I, Mishra, V, Bhaumik, P. Deposit date: 2017-10-03 Release date: 2018-07-11 Last modified: 2019-05-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Febs J., 285, 2018
8FDA	Human Cytochrome P450 17A1 in complex with steroidal isonitrile inhibitor Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase, [(1~{R})-1-[(3~{S},5~{S},8~{R},9~{S},10~{S},13~{S},17~{R})-3-methanoyloxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,13,14,15,16,17-hexadecahydrocyclopenta[a]phenanthren-17-yl]ethyl]-methylidyne-azanium Authors: Richard, A.M, Scott, E.E. Deposit date: 2022-12-02 Release date: 2023-08-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles. Commun Chem, 6, 2023
6AYD	Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide Descriptor: N-[6-(4-hydroxyphenyl)-2H-indazol-3-yl]cyclopropanecarboxamide, Serine/threonine-protein kinase pim-1 Authors: Shewchuk, L.M, Henley, Z.A. Deposit date: 2017-09-08 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome. ACS Med Chem Lett, 8, 2017
5YCG	Ancestral myoglobin aMbWp of Pakicetus relative Descriptor: Ancestral myoglobin aMbWp of Pakicetus relative, PROTOPORPHYRIN IX CONTAINING FE Authors: Isogai, Y, Imamura, H, Nakae, S, Sumi, T, Takahashi, K, Nakagawa, T, Tsuneshige, A, Shirai, T. Deposit date: 2017-09-07 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Tracing whale myoglobin evolution by resurrecting ancient proteins. Sci Rep, 8, 2018
8CS0	Crystal structure of alien DNA CTSZZPBSBSZPPBAG in a host-guest complex with the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase Descriptor: DNA (5'-D(*CP*TP*(JSP)P*(1W5)P*(1W5)P*(1WA)P*(IGU)P*(JSP))-3'), DNA (5'-D(P*(IGU)P*(JSP)P*(1W5)P*(1WA)P*(1WA)P*(IGU)P*AP*G)-3'), reverse transcriptase Authors: Georgiadis, M.M. Deposit date: 2022-05-12 Release date: 2023-05-17 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Alien DNA visualized at high resolution in A- and B-forms To Be Published
8FG4	HRAS R97L Crystal Form 1 Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... Authors: Fetics, S, Johnson, C.W, Mattos, C. Deposit date: 2022-12-12 Release date: 2023-09-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Allosteric site variants affect GTP hydrolysis on Ras. Protein Sci., 32, 2023
4QKH	Dimeric form of human LLT1, a ligand for NKR-P1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D Authors: Skalova, T, Blaha, J, Harlos, K, Duskova, J, Koval, T, Stransky, J, Hasek, J, Vanek, O, Dohnalek, J. Deposit date: 2014-06-06 Release date: 2015-03-11 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states Acta Crystallogr.,Sect.D, 71, 2015

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