8FDA

Human Cytochrome P450 17A1 in complex with steroidal isonitrile inhibitor

Summary for 8FDA

Entry DOI	10.2210/pdb8fda/pdb
Descriptor	Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, [(1~{R})-1-[(3~{S},5~{S},8~{R},9~{S},10~{S},13~{S},17~{R})-3-methanoyloxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,13,14,15,16,17-hexadecahydrocyclopenta[a]phenanthren-17-yl]ethyl]-methylidyne-azanium, ... (4 entities in total)
Functional Keywords	cytochrome p450 17a1, cytochrome p450 c17, 17-alpha hydroxylase, 17, 20 lyase, isonitrile, steroid, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	227571.69
Authors	Richard, A.M.,Scott, E.E. (deposition date: 2022-12-02, release date: 2023-08-23, Last modification date: 2023-09-13)
Primary citation	Richard, A.M.,Wong, N.R.,Harris, K.,Sundar, R.,Scott, E.E.,Pochapsky, T.C. Selective steroidogenic cytochrome P450 haem iron ligation by steroid-derived isonitriles. Commun Chem, 6:183-183, 2023 Cited by PubMed: 37660137 DOI: 10.1038/s42004-023-00994-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation