8FDA

Human Cytochrome P450 17A1 in complex with steroidal isonitrile inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0004508	molecular_function	steroid 17-alpha-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006694	biological_process	steroid biosynthetic process
A	0006702	biological_process	androgen biosynthetic process
A	0006704	biological_process	glucocorticoid biosynthetic process
A	0007548	biological_process	sex differentiation
A	0008202	biological_process	steroid metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016020	cellular_component	membrane
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016829	molecular_function	lyase activity
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030424	cellular_component	axon
A	0042445	biological_process	hormone metabolic process
A	0042446	biological_process	hormone biosynthetic process
A	0042448	biological_process	progesterone metabolic process
A	0043025	cellular_component	neuronal cell body
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0004508	molecular_function	steroid 17-alpha-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006694	biological_process	steroid biosynthetic process
B	0006702	biological_process	androgen biosynthetic process
B	0006704	biological_process	glucocorticoid biosynthetic process
B	0007548	biological_process	sex differentiation
B	0008202	biological_process	steroid metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016020	cellular_component	membrane
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016829	molecular_function	lyase activity
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030424	cellular_component	axon
B	0042445	biological_process	hormone metabolic process
B	0042446	biological_process	hormone biosynthetic process
B	0042448	biological_process	progesterone metabolic process
B	0043025	cellular_component	neuronal cell body
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0004508	molecular_function	steroid 17-alpha-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006694	biological_process	steroid biosynthetic process
C	0006702	biological_process	androgen biosynthetic process
C	0006704	biological_process	glucocorticoid biosynthetic process
C	0007548	biological_process	sex differentiation
C	0008202	biological_process	steroid metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016020	cellular_component	membrane
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016829	molecular_function	lyase activity
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030424	cellular_component	axon
C	0042445	biological_process	hormone metabolic process
C	0042446	biological_process	hormone biosynthetic process
C	0042448	biological_process	progesterone metabolic process
C	0043025	cellular_component	neuronal cell body
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0004508	molecular_function	steroid 17-alpha-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006694	biological_process	steroid biosynthetic process
D	0006702	biological_process	androgen biosynthetic process
D	0006704	biological_process	glucocorticoid biosynthetic process
D	0007548	biological_process	sex differentiation
D	0008202	biological_process	steroid metabolic process
D	0008395	molecular_function	steroid hydroxylase activity
D	0016020	cellular_component	membrane
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016829	molecular_function	lyase activity
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030424	cellular_component	axon
D	0042445	biological_process	hormone metabolic process
D	0042446	biological_process	hormone biosynthetic process
D	0042448	biological_process	progesterone metabolic process
D	0043025	cellular_component	neuronal cell body
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGPRSCIG

Chain	Residue	Details
A	PHE435-GLY444

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:25301938

Chain	Residue	Details
A	ASN202
B	ASN202
C	ASN202
D	ASN202

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS442
B	CYS442
C	CYS442
D	CYS442

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