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8VAT
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BU of 8vat by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Open-RNAp/t conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAN
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BU of 8van by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in an Initial-Binding conformation
Descriptor: Beta sliding clamp, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ...
Authors:Landeck, J.T, Pajak, J, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAR
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BU of 8var by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Closed-DNA2 conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAL
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BU of 8val by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Open-DNAp/t conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAQ
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BU of 8vaq by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Closed-DNA1 conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAP
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BU of 8vap by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Fully-Open conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAM
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BU of 8vam by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in a Semi-Open conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
8VAS
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BU of 8vas by Molmil
Structure of the E. coli clamp loader bound to the beta clamp in an Altered-Collar conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Beta sliding clamp, ...
Authors:Landeck, J.T, Kelch, B.A.
Deposit date:2023-12-11
Release date:2024-03-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
J.Biol.Chem., 300, 2024
7LDD
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BU of 7ldd by Molmil
native AMPA receptor
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Yu, J, Rao, P, Gouaux, E.
Deposit date:2021-01-13
Release date:2021-05-12
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Nature, 594, 2021
7LDE
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BU of 7lde by Molmil
native AMPA receptor
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Yu, J, Rao, P, Gouaux, E.
Deposit date:2021-01-13
Release date:2021-05-12
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition.
Nature, 594, 2021
2JOS
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BU of 2jos by Molmil
Solution structure of piscidin in presence of DPC micelles
Descriptor: Moronecidin
Authors:Campagna, S, Saint, N, Molle, G, Aumelas, A.
Deposit date:2007-03-21
Release date:2007-04-03
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structure and mechanism of action of the antimicrobial peptide piscidin
Biochemistry, 46, 2007
9C3F
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BU of 9c3f by Molmil
Cryo-EM structure of E. coli AmpG
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Anhydromuropeptide permease,Soluble cytochrome b562, DODECYL-BETA-D-MALTOSIDE
Authors:Sverak, H, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2024-05-31
Release date:2024-12-18
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and beta-lactam antibiotic resistance.
Nat Commun, 15, 2024
8Y55
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BU of 8y55 by Molmil
Crystal Structure of NAMPT-PF403
Descriptor: (13~{a}~{S})-6,7-dimethoxy-9,11,12,13,13~{a},14-hexahydrophenanthro[9,10-f]indolizin-3-ol, DI(HYDROXYETHYL)ETHER, Nicotinamide phosphoribosyltransferase
Authors:Yu, S.S, Liu, Y.B, Li, Y.
Deposit date:2024-01-31
Release date:2025-02-19
Last modified:2025-06-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Thermal proteome profiling (TPP) reveals NAMPT as the anti-glioma target of phenanthroindolizidine alkaloid PF403.
Acta Pharm Sin B, 15, 2025
8ATH
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BU of 8ath by Molmil
CRYSTAL STRUCTURE OF LAMP1 IN COMPLEX WITH FAB-B.
Descriptor: Fab B Heavy Chain, Fab B Light Chain, Lysosome-associated membrane glycoprotein 1
Authors:Mathieu, M, Dupuy, A.
Deposit date:2022-08-23
Release date:2023-03-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.366 Å)
Cite:Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold.
Mabs, 15, 2023
8FYF
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BU of 8fyf by Molmil
Human TMEM175-LAMP1 transmembrane domain only complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-26
Release date:2023-06-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
8FY5
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BU of 8fy5 by Molmil
Human TMEM175-LAMP1 full-length complex
Descriptor: Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1
Authors:Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X.
Deposit date:2023-01-25
Release date:2023-06-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
7Q8T
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BU of 7q8t by Molmil
Crystal structure of NAMPT bound to ligand TSY535(compound 9a)
Descriptor: Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate
Authors:Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2021-11-11
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Acta Pharm Sin B, 13, 2023
8YJX
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BU of 8yjx by Molmil
Crystal structure of penicillin-binding protein 2 (PBP2) from Campylobacter jejuni
Descriptor: Penicillin-binding protein 2, ZINC ION
Authors:Choi, H.J, Ki, D.W, Yoon, S.I.
Deposit date:2024-03-03
Release date:2024-04-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural and biochemical analysis of penicillin-binding protein 2 from Campylobacter jejuni.
Biochem.Biophys.Res.Commun., 710, 2024
7PPH
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BU of 7pph by Molmil
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH Compound 10
Descriptor: GLYCEROL, N-[4-[(5R)-6-oxidanylidene-5-quinolin-5-yl-5-(trifluoromethyl)-1,4-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Hillig, R.C.
Deposit date:2021-09-13
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
7PPI
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BU of 7ppi by Molmil
Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11
Descriptor: CHLORIDE ION, GLYCEROL, N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, ...
Authors:Hillig, R.C.
Deposit date:2021-09-13
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
7PPE
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BU of 7ppe by Molmil
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 1
Descriptor: GLYCEROL, N-[4-[(4R)-4-methyl-1-(oxan-4-yl)-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Hillig, R.C.
Deposit date:2021-09-13
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
7PPF
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BU of 7ppf by Molmil
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 8
Descriptor: 1,2-ETHANEDIOL, N-[4-[(4R)-1,4-dimethyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-5,7-dihydropyrrolo[3,4-b]pyridine-6-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Hillig, R.C.
Deposit date:2021-09-13
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
7PPG
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BU of 7ppg by Molmil
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH COMPOUND 9
Descriptor: 1,2-ETHANEDIOL, N-[4-[(4R)-1-cyclopentyl-4-methyl-6-oxidanylidene-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ...
Authors:Hillig, R.C.
Deposit date:2021-09-13
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Bioconjug.Chem., 33, 2022
5FXT
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BU of 5fxt by Molmil
Crystal Structure of Helicobacter pylori beta clamp in complex with Carprofen
Descriptor: (2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid, DNA POLYMERASE III SUBUNIT BETA
Authors:Pandey, P, Gourinath, S.
Deposit date:2016-03-02
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.
Antibiotics (Basel), 7, 2018
6YEO
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BU of 6yeo by Molmil
Crystal structure of AmpC from E. coli with cyclic boronate 2
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (4~{R})-4-[[4-(aminomethyl)phenyl]carbonylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Lang, P.A, Schofield, C.J, Brem, J.
Deposit date:2020-03-25
Release date:2020-06-24
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli .
Biomolecules, 10, 2020

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數據於2025-07-09公開中

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