7PPI

Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11

Summary for 7PPI

Entry DOI	10.2210/pdb7ppi/pdb
Descriptor	Nicotinamide phosphoribosyltransferase, N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	small molecule inhibitor, nmprtase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	225646.79
Authors	Hillig, R.C. (deposition date: 2021-09-13, release date: 2022-06-15, Last modification date: 2024-01-31)
Primary citation	Bohnke, N.,Berger, M.,Griebenow, N.,Rottmann, A.,Erkelenz, M.,Hammer, S.,Berndt, S.,Gunther, J.,Wengner, A.M.,Stelte-Ludwig, B.,Mahlert, C.,Greven, S.,Dietz, L.,Jorissen, H.,Barak, N.,Bomer, U.,Hillig, R.C.,Eberspaecher, U.,Weiske, J.,Giese, A.,Mumberg, D.,Nising, C.F.,Weinmann, H.,Sommer, A. A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug.Chem., 33:1210-1221, 2022 Cited by PubMed: 35658441 DOI: 10.1021/acs.bioconjchem.2c00178 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation