7PPI
Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nicotinamide phosphoribosyltransferase | polymer | 492 | 55652.0 | 4 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (Human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | E, K, N, U (A, B, C, D) | N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide | non-polymer | 533.6 | 4 | Chemie (7Z2) | |||
| 3 | F, L, O, V (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 4 | G, I, J, M, P... (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 5 | H, Q, T (A, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 1146 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 222608.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3038.8 | |
| All* | Total formula weight | 225646.8 |
