7Q8T

Crystal structure of NAMPT bound to ligand TSY535(compound 9a)

Summary for 7Q8T

• Entry DOI: 10.2210/pdb7q8t/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate, SULFATE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, activator, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 113653.91

Authors

Kraemer, A.,Tang, S.,Butterworth, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-11-11, release date: 2021-11-24, Last modification date: 2024-01-31)

• Primary citation: Tang, S.,Garzon Sanz, M.,Smith, O.,Kramer, A.,Egbase, D.,Caton, P.W.,Knapp, S.,Butterworth, S.; Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.; Acta Pharm Sin B, 13:709-721, 2023; PubMed: 36873168; DOI: 10.1016/j.apsb.2022.07.016

Experimental method

X-RAY DIFFRACTION (2.15 Å)