7Q8T
Crystal structure of NAMPT bound to ligand TSY535(compound 9a)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 497 | 56152.4 | 2 | UniProt (Q99KQ4) Pfam (PF18127) Pfam (PF04095) In PDB | Mus musculus (Mouse) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1 homolog,PBEF,Visfatin |
| 2 | A, B | [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | non-polymer | 578.5 | 2 | Chemie (9IY) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 751 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: Q99KQ4)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112304.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1349.2 | |
| All* | Total formula weight | 113653.9 |
