7PPH

CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH Compound 10

Summary for 7PPH

• Entry DOI: 10.2210/pdb7pph/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, N-[4-[(5R)-6-oxidanylidene-5-quinolin-5-yl-5-(trifluoromethyl)-1,4-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: small molecule inhibitor, nmprtase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 113113.24

Authors

Hillig, R.C. (deposition date: 2021-09-13, release date: 2022-06-15, Last modification date: 2024-01-31)

• Primary citation: Bohnke, N.,Berger, M.,Griebenow, N.,Rottmann, A.,Erkelenz, M.,Hammer, S.,Berndt, S.,Gunther, J.,Wengner, A.M.,Stelte-Ludwig, B.,Mahlert, C.,Greven, S.,Dietz, L.,Jorissen, H.,Barak, N.,Bomer, U.,Hillig, R.C.,Eberspaecher, U.,Weiske, J.,Giese, A.,Mumberg, D.,Nising, C.F.,Weinmann, H.,Sommer, A.; A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.; Bioconjug.Chem., 33:1210-1221, 2022; PubMed: 35658441; DOI: 10.1021/acs.bioconjchem.2c00178

Experimental method

X-RAY DIFFRACTION (1.74 Å)