7PPH
CRYSTAL STRUCTURE OF NAMPT IN COMPLEX WITH Compound 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 492 | 55652.0 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (Human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | C, H (A, B) | N-[4-[(5R)-6-oxidanylidene-5-quinolin-5-yl-5-(trifluoromethyl)-1,4-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide | non-polymer | 530.5 | 2 | Chemie (7YE) | |||
| 3 | D, E, I, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 4 | F, G, K, L (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 886 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111304.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1809.3 | |
| All* | Total formula weight | 113113.2 |
