Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8VZE
DownloadVisualize
BU of 8vze by Molmil
Crystal Structure of 2-Hydroxyacyl-CoA lyase/synthase TbHACS from Thermoflexaceae bacterium in the Complex with THDP, 2-Hydroxyisobutyryl-CoA and ADP
Descriptor: 1,2-ETHANEDIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(hydroxymethyl)-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kim, Y, Maltseva, M, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
5VFY
DownloadVisualize
BU of 5vfy by Molmil
Structure of an accessory protein of the pCW3 relaxosome
Descriptor: TcpK
Authors:Traore, D.A.K, Wisniewski, J.A, Flanigan, S.F, Conroy, P.J, Panjikar, S, Mok, Y.-F, Lao, C, Griffin, M.D.W, Adams, V, Rood, J.I, Whisstock, J.C.
Deposit date:2017-04-10
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.
Nat Commun, 9, 2018
6VJC
DownloadVisualize
BU of 6vjc by Molmil
LmFPPS mutant T164Y in complex with 476A, IPP & Ca
Descriptor: 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ...
Authors:Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B.
Deposit date:2020-01-15
Release date:2020-11-25
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
8VJL
DownloadVisualize
BU of 8vjl by Molmil
SpoIVFB:pro-sigmaK complex
Descriptor: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Lauryl Maltose Neopentyl Glycol, RNA polymerase sigma factor, ...
Authors:Orlando, M.A, Pouillon, H.J.T, Mandal, S, Kroos, L, Orlando, B.J.
Deposit date:2024-01-07
Release date:2024-10-02
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Substrate engagement by the intramembrane metalloprotease SpoIVFB.
Nat Commun, 15, 2024
7LQD
DownloadVisualize
BU of 7lqd by Molmil
Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor
Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, Dual specificity protein kinase TTK or monopolar spindle 1 kinase, GLYCEROL, ...
Authors:Santiago, A.S, dos Reis, C.V, Serafim, R.A.M, Massirer, K.B, Arruda, P, Edwards, A.M, Counago, R.M, Structural Genomics Consortium (SGC)
Deposit date:2021-02-13
Release date:2022-02-16
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
J.Med.Chem., 65, 2022
8VZH
DownloadVisualize
BU of 8vzh by Molmil
Crystal Structure of 2-Hydroxyacyl-CoA lyase/synthase TbHACS from Thermoflexaceae bacterium in the Complex with THDP and ADP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Kim, Y, Maltseva, M, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
8VZK
DownloadVisualize
BU of 8vzk by Molmil
Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase CfhHACS from Chloroflexi bacterium in the Complex with THDP and ADP
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Kim, Y, Gade, P, Mayfield, A, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
6VKZ
DownloadVisualize
BU of 6vkz by Molmil
Crystal Structure of the N-prenyltransferase DabA in Complex with GSPP and Mg2+
Descriptor: DabA, GERANYL S-THIOLODIPHOSPHATE, MAGNESIUM ION
Authors:Chekan, J.R, Noel, J.P, Moore, B.S.
Deposit date:2020-01-22
Release date:2020-04-08
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into anN-prenyltransferase.
Proc.Natl.Acad.Sci.USA, 117, 2020
8VZA
DownloadVisualize
BU of 8vza by Molmil
Crystal Structure of 2-Hydroxacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, L-Lactyl-CoA, and ADP
Descriptor: 2-Hydroxyacyl-CoA lyase/Synthase, 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ACETYL GROUP, ...
Authors:Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
5IQX
DownloadVisualize
BU of 5iqx by Molmil
1.05A resolution structure of Holo HasAp (R33A) from Pseudomonas aeruginosa
Descriptor: D-MALATE, Heme acquisition protein HasAp, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Kumar, R, Lovell, S, Battaile, K.P, Yao, H, Rivera, M.
Deposit date:2016-03-11
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Replacing Arginine 33 for Alanine in the Hemophore HasA from Pseudomonas aeruginosa Causes Closure of the H32 Loop in the Apo-Protein.
Biochemistry, 55, 2016
8VZB
DownloadVisualize
BU of 8vzb by Molmil
Crystal Structure of 2-Hydroxacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, D-Lactyl-CoA, and ADP
Descriptor: 1,2-ETHANEDIOL, 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ACETIC ACID, ...
Authors:Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
5VH3
DownloadVisualize
BU of 5vh3 by Molmil
Crystal structure of Fab fragment of the anti-TNFa antibody infliximab in a C-centered orthorhombic crystal form
Descriptor: 1,2-ETHANEDIOL, Infliximab Fab Heavy Chain, Infliximab Fab Light Chain
Authors:Mayclin, S.J, Edwards, T.E, Lerch, T.F, Conlan, H, Sharpe, P.
Deposit date:2017-04-12
Release date:2017-05-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Infliximab crystal structures reveal insights into self-association.
MAbs, 9, 2017
5ITD
DownloadVisualize
BU of 5itd by Molmil
Crystal structure of PI3K alpha with PI3K delta inhibitor
Descriptor: 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Knapp, M.S, Elling, R.A.
Deposit date:2016-03-16
Release date:2016-09-07
Last modified:2025-04-09
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Acs Med.Chem.Lett., 7, 2016
8VZI
DownloadVisualize
BU of 8vzi by Molmil
Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase CcHACS from Conidiobolus coronatus in the Complex with THDP and ADP
Descriptor: 1,2-ETHANEDIOL, 2-hydroxyacyl-CoA lyase-like protein 1, ACETATE ION, ...
Authors:Kim, Y, Gade, P, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
5VHG
DownloadVisualize
BU of 5vhg by Molmil
Crystal structure of pentad mutant GAPR-1
Descriptor: Golgi-associated plant pathogenesis-related protein 1, SULFATE ION
Authors:Li, Y, Zhao, Y, Su, M, Chakravarthy, S, Colbert, C.L, Levine, B, Sinha, S.C.
Deposit date:2017-04-13
Release date:2017-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein.
Acta Crystallogr D Struct Biol, 73, 2017
6VLM
DownloadVisualize
BU of 6vlm by Molmil
Core Catalytic Domain of HIV Integrase in complex with virtual screening hit
Descriptor: Integrase, [3-(4-chlorophenyl)[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
Authors:Klein, D.J, Sanders, J.M.
Deposit date:2020-01-24
Release date:2020-05-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J.Chem.Inf.Model., 60, 2020
8W0I
DownloadVisualize
BU of 8w0i by Molmil
Cryo-EM structure of the human MCM2-7 heterohexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor MCM2, ...
Authors:Yang, R, Hunker, O, Bleichert, F.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Multiple mechanisms for licensing human replication origins.
Nature, 636, 2024
7LK1
DownloadVisualize
BU of 7lk1 by Molmil
Ornithine Aminotransferase (OAT) with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148) - 1 Hour Soaking
Descriptor: (1R,4R)-4-fluoro-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]cyclopent-2-ene-1-carboxylic acid, Ornithine aminotransferase, mitochondrial
Authors:Butrin, A, Shen, S, Liu, D, Silverman, R.
Deposit date:2021-02-01
Release date:2022-02-16
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase.
J.Am.Chem.Soc., 143, 2021
7LO0
DownloadVisualize
BU of 7lo0 by Molmil
Structure of human ASF1a in complex with a TLK2 peptide
Descriptor: Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2
Authors:Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J.
Deposit date:2021-02-08
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
8VDL
DownloadVisualize
BU of 8vdl by Molmil
HB3VAR03 CIDRa1.4 domain with C7 Fab
Descriptor: C7 Heavy Chain, C7 Light Chain, HB3VAR03 CIDRa1.4 domain, ...
Authors:Hurlburt, N.K, Pancera, M.
Deposit date:2023-12-15
Release date:2024-10-09
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Broadly inhibitory antibodies to severe malaria virulence proteins.
Nature, 636, 2024
7LSD
DownloadVisualize
BU of 7lsd by Molmil
Crystal structure of near-infrared fluorescent protein miRFP718nano
Descriptor: BILIVERDINE IX ALPHA, miRFP718nano
Authors:Pletnev, S.
Deposit date:2021-02-18
Release date:2022-02-23
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rational design of a small near-infrared fluorescent protein from CBCR suitable for deep-tissue SWIR imaging.
To Be Published
5VHX
DownloadVisualize
BU of 5vhx by Molmil
GluA2-1xGSG1L bound to ZK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Germ cell-specific gene 1-like protein, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I.
Deposit date:2017-04-13
Release date:2017-05-03
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
Neuron, 94, 2017
8VH5
DownloadVisualize
BU of 8vh5 by Molmil
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ...
Authors:Zhu, H, Sun, J.
Deposit date:2023-12-30
Release date:2024-10-09
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Nat Commun, 15, 2024
8VZC
DownloadVisualize
BU of 8vzc by Molmil
Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthse ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, Formyl-CoA, and ADP
Descriptor: 1,2-ETHANEDIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(hydroxymethyl)-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Gade, P, Kim, Y, Endres, M, Lee, S, Yoshikuni, Y, Gonzalez, R, Michalska, K, Joachimiak, A.
Deposit date:2024-02-11
Release date:2024-10-02
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.
Commun Chem, 7, 2024
8VX6
DownloadVisualize
BU of 8vx6 by Molmil
Human OGG1 bound at the nucleosomal DNA entry site
Descriptor: DNA (167-MER), Histone H2A, Histone H2B 1.1, ...
Authors:You, Q, Li, H.
Deposit date:2024-02-03
Release date:2024-10-09
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations.
Commun Biol, 7, 2024

243531

數據於2025-10-22公開中

PDB statisticsPDBj update infoContact PDBjnumon